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The significant influence of tumor microenvironment on malignant cells has been investigated with enthusiasm in this era of… Expand Stromal–epithelial interactions are important in both development and prostate cancer. Stromal changes have been shown to be… Expand Approximately 50% of patients with muscle-invasive bladder cancer (MIBC) develop metastatic disease, which is almost invariably… Expand Carcinoma-associated fibroblasts (CAF) play a critical role in malignant progression. Loss of TGF-β receptor II (TGFβR2) in the… Expand Prostate cancer develops through a stochastic mechanism whereby precancerous lesions on occasion progress to multifocal… Expand We have sought to develop a new in vivo model of prostate carcinogenesis using human prostatic epithelial cell cultures. Human… Expand Transforming growth factor-beta1 (TGF-beta 1) is a pluripotent cytokine that can inhibit epithelial proliferation and induce… Expand In order to study anteroposterior neural patterning in Xenopus embryos, we have developed a novel assay using explants and tissue… Expand Classic studies on experimental embryology have shown that organ development in an embryo is largely regulated by so called… Expand Syndecan is an integral cell surface proteoglycan which contains an extracellular matrix-binding domain and a cytoskeleton… Expand