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Avian hairy Gene Expression Identifies a Molecular Clock Linked to Vertebrate Segmentation and Somitogenesis
We have identified and characterized c-hairy1, an avian homolog of the Drosophila segmentation gene, hairy. c-hairy1 is strongly expressed in the presomitic mesoderm, where its mRNA exhibits cyclicExpand
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FGF Signaling Controls Somite Boundary Position and Regulates Segmentation Clock Control of Spatiotemporal Hox Gene Activation
Vertebrate segmentation requires a molecular oscillator, the segmentation clock, acting in presomitic mesoderm (PSM) cells to set the pace at which segmental boundaries are laid down. However, theExpand
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Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genomeExpand
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Lateral and Axial Signals Involved in Avian Somite Patterning: A Role for BMP4
In vertebrates, muscles of the limbs and body wall derive from the lateral compartment of the embryonic somites, and axial muscles derive from the medial compartment. Whereas the mechanisms thatExpand
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Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm.
Somitic segmentation provides the framework on which the segmental pattern of the vertebrae, some muscles and the peripheral nervous system is established. Recent evidence indicates that a molecularExpand
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Maintenance of neuroepithelial progenitor cells by Delta–Notch signalling in the embryonic chick retina
BACKGROUND Neurons of the vertebrate central nervous system (CNS) are generated sequentially over a prolonged period from dividing neuroepithelial progenitor cells. Some cells in the progenitor cellExpand
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fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo
Formation and patterning of the vertebrate embryo occur in a head-to-tail sequence. This progressive mode of body formation from the posterior end of the embryo requires a strict temporalExpand
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Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning.
In the vertebrate embryo, the lateral compartment of the somite gives rise to muscles of the limb and body wall and is patterned in response to lateral-plate-derived BMP4. Activation of the myogenicExpand
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Segmental patterning of the vertebrate embryonic axis
The body axis of vertebrates is composed of a serial repetition of similar anatomical modules that are called segments or metameres. This particular mode of organization is especially conspicuous atExpand
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A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock
The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of theExpand
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