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Tilorone

Known as: 9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-, Bis DEAE Fluorenone, Tilorone [Chemical/Ingredient] 
An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon… 
National Institutes of Health

Related topics

Related topics

17 relations

Broader (4)

Anti-Inflammatory AgentsAntineoplastic AgentsAntiviral AgentsInterferon Inducers

Narrower (5)

IS 23IS 33LoramyxineVUFB 14162
In BloodTilorone Hydrochlorideagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Palladium-catalyzed cyclocoupling of 2-halobiaryls with isocyanides via the cleavage of carbon-hydrogen bonds.
To demonstrate the utility of isocyanides in catalytic C-H bond functionalization reactions, a palladium-catalyzed cyclocoupling… 
2006
2006
Photodegradation of polyfluorene and fluorene oligomers with alkyl and aromatic disubstitutions.
The stability of fluorene-based compounds and polymers, especially at the bridged C-9 position under photoirradiation and thermal… 
1996
1996
The antimalarials quinacrine and chloroquine induce weak lysosomal storage of sulphated glycosaminoglycans in cell culture and in vivo.
1988
1988
Energetics and stereochemistry of DNA complexation with the antitumor AT specific intercalators tilorone and m-AMSA.
Computations by the SIBFA method on the intercalative interaction energies of tilorone and m-AMSA with B-DNA representative… 
1986
1986
Enhancement of host resistance against virus infections by MTP-PE, a synthetic lipophilic muramyl peptide--I. Increased survival in mice and guinea pigs after single drug administration prior to…
1984
1984
Tilorone acts as a lysosomotropic agent in fibroblasts.
Tilorone, an amphiphilic cationic compound with antiviral activity perturbed the lysosomal system. In cultured fibroblasts… 
Highly Cited
1979
Highly Cited
1979
Enhancement by interferon of natural killer cell activity in mice.
Highly Cited
1976
Highly Cited
1976
Augmentation of specific macrophage-mediated cytotoxicity: correlations with agents which enhance antitumor resistance.
1974
1974
T cell rosette formation in primates, pigs, and guinea pigs. The influence of immunosuppresive agents.
1974
1974
Tilorone: Its Selective Effects on Humoral and Cell-Mediated Immunity 1
Summary We have shown selective activity of tilorone with regard to humoral and cell-mediated responses. The compound enhanced… 
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