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Th17 Cells

Known as: TH-17 Cell, TH 17 Cells, Type 17 Helper T Cells 
A subset of helper T-lymphocytes which synthesize and secrete the interleukins (IL), IL-17A, -21 and -22. These cytokines mediate inflammation by… 
National Institutes of Health

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Hematopoietic and Lymphoid TissueLymphoid TissueMicrobiologicalProcess of secretion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling
The role of T-helper type 17 (Th17) responses in airway remodeling in asthma is currently unknown. We demonstrate that both… 
Highly Cited
2010
Highly Cited
2010
Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
IntroductionInterleukin (IL)-17 is a proinflammatory cytokine that is produced largely by a unique CD4+ T-helper (Th) subset… 
Highly Cited
2010
Highly Cited
2010
Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis.
A major target autoantigen in anti-neutrophil cytoplasmic antibody-associated vasculitis is myeloperoxidase (MPO). Although MPO… 
Review
2010
Review
2010
The Th17 immune response in renal inflammation.
The discovery of interleukin (IL)-17-producing CD4(+) T (Th17) cells as a unique T-helper cell lineage has revised our… 
Highly Cited
2009
Highly Cited
2009
Th17 Immunity in Patients with Allergic Asthma
Background: Allergic asthma is an inflammatory disease regulated by the T helper (Th) cells. The Th1/Th2 imbalance has been well… 
Review
2009
Review
2009
Precarious Balance: Th17 Cells in Host Defense
ABSTRACT Lineage-specific responses from the effector T-cell repertoire form a critical component of adaptive immunity. The… 
Review
2008
Review
2008
Th17 cells in immunity and autoimmunity
The primary function of Th17 cells appears to be the clearance of extracellular pathogens during infections. However, Th17 cells… 
Highly Cited
2008
Highly Cited
2008
Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-γ on STAT3 and Smads1
Suppressor of cytokine signaling 1 (SOCS1) is an important negative regulator for cytokines; however, the role of SOCS1 in Th17… 
Highly Cited
2008
Highly Cited
2008
TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease
T helper type 17 (Th17) cells play an important pathogenic function in autoimmune diseases; their regulation, however, is not… 
Highly Cited
2007
Highly Cited
2007
Autoimmune inflammation from the Th17 perspective.
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