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Tetrodotoxin

Known as: Tarichatoxin, TTX, Tetradotoxin 
A neurotoxin with potential analgesic activity. Tetrodotoxin binds to the pores of fast voltage-gated fast sodium channels in nerve cell membranes… Expand
National Institutes of Health

Papers overview

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Highly Cited
1999
Highly Cited
1999
Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium channels. Here we examined the role of the… Expand
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Highly Cited
1997
Highly Cited
1997
Clinical and experimental studies have shown that spinal sensory neurons become hyperexcitable after axonal injury, and… Expand
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Highly Cited
1996
Highly Cited
1996
DORSAL root ganglion sensory neurons associated with C-fibres, many of which are activated by tissue-damage, express an unusual… Expand
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Highly Cited
1996
Highly Cited
1996
Sensitization of primary afferent neurons underlies much of the pain and tenderness associated with tissue injury and… Expand
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Highly Cited
1995
Highly Cited
1995
Mouse embryonic stem (ES) cells cultured as aggregates and exposed to retinoic acid are induced to express multiple phenotypes… Expand
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Highly Cited
1992
Highly Cited
1992
The principal voltage-sensitive sodium channel from human heart has been cloned, sequenced, and functionally expressed. The cDNA… Expand
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Highly Cited
1992
Highly Cited
1992
Increased activity of dopamine-containing neurons in the ventral tegmental area is necessary for the reinforcing effects of… Expand
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Highly Cited
1992
Highly Cited
1992
TTX-sensitive (TTX-S) and TTX-resistant (TTX-R) sodium channel currents were analyzed in acutely dissociated dorsal root ganglion… Expand
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Highly Cited
1988
Highly Cited
1988
In the adult mammalian visual system, ganglion cell axons from the two eyes are segregated from each other into separate layers… Expand
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Highly Cited
1964
Highly Cited
1964
Previous studies suggested that tetrodotoxin, a poison from the puffer fish, blocks conduction of nerve and muscle through its… Expand
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