Tetrodotoxin

Known as: Tarichatoxin, TTX, Tetradotoxin 
A neurotoxin with potential analgesic activity. Tetrodotoxin binds to the pores of fast voltage-gated fast sodium channels in nerve cell membranes… (More)
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
Neuropathic pain is a debilitating chronic syndrome that often arises from injuries to peripheral nerves. Such pain has been… (More)
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Review
2000
Review
2000
tetrodotoxin binding activity and a protein of ‫072ف‬ kDa (Agnew et al., 1980). Subsequent purification studies showed that the… (More)
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Highly Cited
1999
Highly Cited
1999
Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium channels. Here we examined the role of the… (More)
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Highly Cited
1999
Highly Cited
1999
TTX-resistant (TTX-R) sodium currents are preferentially expressed in small C-type dorsal root ganglion (DRG) neurons, which… (More)
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Highly Cited
1997
Highly Cited
1997
Clinical and experimental studies have shown that spinal sensory neurons become hyperexcitable after axonal injury, and… (More)
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Highly Cited
1996
Highly Cited
1996
DORSAL root ganglion sensory neurons associated with C-fibres, many of which are activated by tissue-damage, express an unusual… (More)
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Highly Cited
1996
Highly Cited
1996
Sensitization of primary afferent neurons underlies much of the pain and tenderness associated with tissue injury and… (More)
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Highly Cited
1992
Highly Cited
1992
TTX-sensitive (TTX-S) and TTX-resistant (TTX-R) sodium channel currents were analyzed in acutely dissociated dorsal root ganglion… (More)
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Highly Cited
1969
Highly Cited
1969
1. The electric properties of the giant synapse in the stellate ganglion of the squid have been further investigated.2. During… (More)
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Highly Cited
1964
Highly Cited
1964
Previous studies suggested that tetrodotoxin, a poison from the puffer fish, blocks conduction of nerve and muscle through its… (More)
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