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Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium channels. Here we examined the role of the… Expand Clinical and experimental studies have shown that spinal sensory neurons become hyperexcitable after axonal injury, and… Expand DORSAL root ganglion sensory neurons associated with C-fibres, many of which are activated by tissue-damage, express an unusual… Expand Sensitization of primary afferent neurons underlies much of the pain and tenderness associated with tissue injury and… Expand The principal voltage-sensitive sodium channel from human heart has been cloned, sequenced, and functionally expressed. The cDNA… Expand Increased activity of dopamine-containing neurons in the ventral tegmental area is necessary for the reinforcing effects of… Expand In the adult mammalian visual system, ganglion cell axons from the two eyes are segregated from each other into separate layers… Expand 1. Intradendritic recordings from Purkinje cells in vitro indicate that white matter stimulation produces large synaptic… Expand 1. The hypothesis is put forward that a residue of the ‘active calcium’ which enters the terminal axon membrane during the nerve… Expand Previous studies suggested that tetrodotoxin, a poison from the puffer fish, blocks conduction of nerve and muscle through its… Expand