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The role of calcium in neuromuscular facilitation
1. The hypothesis is put forward that a residue of the ‘active calcium’ which enters the terminal axon membrane during the nerve impulse is responsible for short‐term facilitation.
The measurement of synaptic delay, and the time course of acetylcholine release at the neuromuscular junction
The synaptic interval arises chiefly from a delay in the release of transmitter after the arrival of the nerve impulse, and the contribution of various factors to the minimum synaptic delay are discussed. Expand
Cholinergic and catecholaminergic receptors in the Xenopus oocyte membrane
Neurotransmitter‐receptors in the membrane of Xenopus oocytes have been studied using electrophysiological techniques and the majority of ovarian oocytes used were at stages IV and V. Expand
Design and in vitro pharmacology of a selective gamma-aminobutyric acidC receptor antagonist.
- D. Ragozzino, R. Woodward, Y. Murata, F. Eusebi, L. Overman, R. Miledi
- Biology, Medicine
- Molecular pharmacology
- 1 October 1996
(1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid (TPMPA), a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABAC receptors but not to interact with GABAA or GABAB receptors, is reported. Expand
Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes.
- C. Matute, M. Sánchez-gómez, L. Martı́nez-Millán, R. Miledi
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 5 August 1997
It is suggested that excessive activation of the ionotropic glutamate receptors expressed by oligodendrocytes may act as a negative regulator of the size of this cell population. Expand
A study of synaptic transmission in the absence of nerve impulses
The axo‐axonic giant synapse in the stellate ganglion of the squid has been used to study synaptic transmission and provides new insights into the role of Tournaisian reprograming in synaptic transmission. Expand
The statistical nature of the acetylcholine potential and its molecular components
1. When a steady dose of acetylcholine is applied to an end‐plate, the resulting depolarization is accompanied by a significant increase in voltage noise, and this noise can be significant in both the positive and the negative directions. Expand
A calcium-dependent transient outward current in Xenopus laevis oocytes
- R. Miledi
- Chemistry, Medicine
- Proceedings of the Royal Society of London…
- 22 July 1982
It appears that when the membrane is depolarized Ca2+ ions enter the oocyte and trigger an outward current, possibly by opening Cl– channels, according to Xenopus laevis oocytes. Expand
The effect of temperature on the synaptic delay at the neuromuscular junction.
The timing of calcium action during neuromuscular transmission
Brief depolarizing pulses applied to a motor nerve ending cause packets of acetylcholine to be released and evoke end‐plate potentials (e.p.s), provided calcium ions are present in the extracellular fluid. Expand