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The role of calcium in neuromuscular facilitation
1. The hypothesis is put forward that a residue of the ‘active calcium’ which enters the terminal axon membrane during the nerve impulse is responsible for short‐term facilitation.
The measurement of synaptic delay, and the time course of acetylcholine release at the neuromuscular junction
The synaptic interval arises chiefly from a delay in the release of transmitter after the arrival of the nerve impulse, and the contribution of various factors to the minimum synaptic delay are discussed.
Design and in vitro pharmacology of a selective gamma-aminobutyric acidC receptor antagonist.
- D. Ragozzino, R. Woodward, Y. Murata, F. Eusebi, L. Overman, R. Miledi
- Biology, ChemistryMolecular Pharmacology
- 1 October 1996
(1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid (TPMPA), a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABAC receptors but not to interact with GABAA or GABAB receptors, is reported.
Cholinergic and catecholaminergic receptors in the Xenopus oocyte membrane
Neurotransmitter‐receptors in the membrane of Xenopus oocytes have been studied using electrophysiological techniques and the majority of ovarian oocytes used were at stages IV and V.
A calcium-dependent transient outward current in Xenopus laevis oocytes
- R. Miledi
- BiologyProceedings of the Royal Society of London…
- 22 July 1982
It appears that when the membrane is depolarized Ca2+ ions enter the oocyte and trigger an outward current, possibly by opening Cl– channels, according to Xenopus laevis oocytes.
Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes.
- C. Matute, M. Sánchez-Gómez, L. Martı́nez-Millán, R. Miledi
- BiologyProceedings of the National Academy of Sciences…
- 5 August 1997
It is suggested that excessive activation of the ionotropic glutamate receptors expressed by oligodendrocytes may act as a negative regulator of the size of this cell population.
The statistical nature of the acetylcholine potential and its molecular components
1. When a steady dose of acetylcholine is applied to an end‐plate, the resulting depolarization is accompanied by a significant increase in voltage noise, and this noise can be significant in both the positive and the negative directions.
A study of synaptic transmission in the absence of nerve impulses
The axo‐axonic giant synapse in the stellate ganglion of the squid has been used to study synaptic transmission and provides new insights into the role of Tournaisian reprograming in synaptic transmission.
Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory.
The anomalous expression of both Cl(-) transporters, NKCC1 and KCC2 [corrected] in TLE hippocampal subiculum probably causes altered Cl(+) transport in the "epileptic" neurons, as revealed in the microtransplanted Xenopus oocytes, and renders GABA aberrantly "exciting," a feature that may contribute to the precipitation of epileptic seizures.
Propagation of electric activity in motor nerve terminals
External micro-electrodes were used to stimulate non-myelinated motor nerve terminals and to record pre- and post-synaptic responses at the neuromuscular junction of the frog to determine the velocity of impulse propagation in motor nerve endings.