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Talsaclidine

Known as: (3R)-3-(2-Propynyloxy)quinuclidine 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2016
012319972016

Papers overview

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2009
2009
Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists.
In functional assay assessments using the five muscarinic receptor subtypes, a second generation of muscarinic M(1)-preferring… (More)
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2003
2003
Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease.
The amyloid beta-peptides A beta 40 and A beta 42 are highly amyloidogenic constituents of brain beta-amyloid plaques in… (More)
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2002
2002
Memory-related task performance by aged rhesus monkeys administered the muscarinic M1-preferring agonist, talsaclidine
Abstract Rationale. Muscarinic-acetylcholine receptor agonists are yet to be used clinically for the treatment of Alzheimer's… (More)
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2001
2001
Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man.
In functional pharmacological assays, talsaclidine has been described as a functionally preferential M1 agonist with full… (More)
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2000
2000
Treatment with the selective muscarinic agonist talsaclidine decreases cerebrospinal fluid levels of total amyloid beta-peptide in patients with Alzheimer's disease.
Brain amyloid load in Alzheimer's disease (AD) is, at least in genetic forms, associated with overproduction of amyloid beta… (More)
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2000
2000
Pharmacokinetics of the M1-agonist talsaclidine in mouse, rat, rabbit and monkey, and extrapolation to man.
1. Talsaclidine is an M1-agonist under development for the treatment of Alzheimer's disease. The aim of the study was to… (More)
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1999
1999
Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats.
The purpose of our studies was to determine the effects of muscarinic receptor agonists on conditioned avoidance responding in… (More)
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1997
1997
Compensation of muscarinic bronchial effects of talsaclidine by concomitant sympathetic activation in guinea pigs.
The aim of the present investigation was to determine the reasons why the muscarinic receptor agonist talsaclidine (WAL 2014 FU… (More)
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1997
1997
In vivo consequences of M1-receptor activation by talsaclidine.
The aim of this investigation in anaesthetized dogs was to provide direct evidence for an activation of the sympathetic nervous… (More)
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1997
1997
Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain.
Amyloid deposits in Alzheimer's disease are composed of amyloid beta-peptides (A beta) that are derived from the larger amyloid… (More)
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