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Talsaclidine
Known as:
(3R)-3-(2-Propynyloxy)quinuclidine
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET
A. Schlessinger
,
Ethan G. Geier
,
+4 authors
A. Sali
Proceedings of the National Academy of Sciences
2011
Corpus ID: 8407981
The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine…
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Highly Cited
2009
Highly Cited
2009
Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists.
J. Heinrich
,
J. Butera
,
+10 authors
S. Mayer
European journal of pharmacology
2009
Corpus ID: 30525444
Review
2007
Review
2007
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer’s disease
A. Fisher
,
Z. Pittel
,
+7 authors
R. Brandeis
Journal of Molecular Neuroscience
2007
Corpus ID: 43653948
M1 muscarinic receptors (M1 mAChRs) play a role in an apparent linkage of three major hallmarks of Alzheimer’s disease (AD…
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Highly Cited
2004
Highly Cited
2004
Beta‐secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling
Thole Züchner
,
J. Perez-polo
,
R. Schliebs
Journal of neuroscience research
2004
Corpus ID: 21914588
The β‐amyloid peptides derived by proteolytic cleavage from the amyloid precursor protein (APP) play a major role in the…
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Highly Cited
2003
Highly Cited
2003
Treatment with the selective muscarinic ml agonist talsaclidine decreases cerebrospinal fluid levels of Aβ42 in patients with Alzheimer's disease
C. Hock
,
A. Maddalena
,
+11 authors
R. Nitsch
Amyloid : the international journal of…
2003
Corpus ID: 24681935
The amyloid p-peptides Aβ40 and Aβ42 are highly amyloidogenic constituents of brain Pamyloid plaques in Alzheimer's disease (AD…
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2002
2002
Memory-related task performance by aged rhesus monkeys administered the muscarinic M1-preferring agonist, talsaclidine
A. Terry
,
J. Buccafusco
,
F. Borsini
,
A. Leusch
Psychopharmacology
2002
Corpus ID: 23323985
HeadingAbstractRationale. Muscarinic-acetylcholine receptor agonists are yet to be used clinically for the treatment of Alzheimer…
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2002
2002
Talsaclidine (WAL 2014 FU), a muscarinic M1 receptor agonist for the treatment of Alzheimer's disease
M. Wienrich
,
A. Ceci
,
+5 authors
T. Weiser
2002
Corpus ID: 71972913
Since the discovery of muscarinic receptor subtypes, extensive research has been going on attempting to provide treatments for…
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Highly Cited
2000
Highly Cited
2000
Treatment with the Selective Muscarinic Agonist Talsaclidine Decreases Cerebrospinal Fluid Levels of Total Amyloid β‐Peptide in Patients with Alzheimer's Disease
C. Hock
,
A. Maddalena
,
+8 authors
R. Nitsch
Annals of the New York Academy of Sciences
2000
Corpus ID: 44635291
Abstract: Brain amyloid load in Alzheimer's disease (AD) is, at least in genetic forms, associated with overproduction of amyloid…
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Highly Cited
1999
Highly Cited
1999
Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats.
H. Shannon
,
J. Hart
,
+9 authors
Michael D B Swedberg
The Journal of pharmacology and experimental…
1999
Corpus ID: 5174976
The purpose of our studies was to determine the effects of muscarinic receptor agonists on conditioned avoidance responding in…
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Highly Cited
1997
Highly Cited
1997
Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain.
D. M. Müller
,
K. Mendla
,
S. Farber
,
R. Nitsch
Life sciences
1997
Corpus ID: 33562422
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