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Talsaclidine

Known as: (3R)-3-(2-Propynyloxy)quinuclidine 
 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET.
The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine… Expand
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2009
2009
Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists.
In functional assay assessments using the five muscarinic receptor subtypes, a second generation of muscarinic M(1)-preferring… Expand
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Review
2007
Review
2007
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer’s disease
M1 muscarinic receptors (M1 mAChRs) play a role in an apparent linkage of three major hallmarks of Alzheimer’s disease (AD… Expand
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2004
2004
Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling.
The beta-amyloid peptides derived by proteolytic cleavage from the amyloid precursor protein (APP) play a major role in the… Expand
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2003
2003
Treatment with the selective muscarinic ml agonist talsaclidine decreases cerebrospinal fluid levels of Aβ42 in patients with Alzheimer's disease
The amyloid p-peptides Aβ40 and Aβ42 are highly amyloidogenic constituents of brain Pamyloid plaques in Alzheimer's disease (AD… Expand
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2002
2002
Memory-related task performance by aged rhesus monkeys administered the muscarinic M1-preferring agonist, talsaclidine
HeadingAbstractRationale. Muscarinic-acetylcholine receptor agonists are yet to be used clinically for the treatment of Alzheimer… Expand
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2001
2001
Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man.
In functional pharmacological assays, talsaclidine has been described as a functionally preferential M1 agonist with full… Expand
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2000
2000
Treatment with the selective muscarinic agonist talsaclidine decreases cerebrospinal fluid levels of total amyloid beta-peptide in patients with Alzheimer's disease.
Brain amyloid load in Alzheimer's disease (AD) is, at least in genetic forms, associated with overproduction of amyloid beta… Expand
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1999
1999
Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats.
The purpose of our studies was to determine the effects of muscarinic receptor agonists on conditioned avoidance responding in… Expand
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1997
1997
Compensation of muscarinic bronchial effects of talsaclidine by concomitant sympathetic activation in guinea pigs.
The aim of the present investigation was to determine the reasons why the muscarinic receptor agonist talsaclidine (WAL 2014 FU… Expand
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