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The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development
TLDR
Cholinergic abnormalities may also contribute to noncognitive behavioral abnormalities as well as the deposition of toxic neuritic plaques in AD and cholinergic-based strategies will likely remain valid as one approach to rational drug development for the treatment of AD other forms of dementia.
Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons
  • Lei Wen, Yisheng Lu, L. Mei
  • Biology, Psychology
    Proceedings of the National Academy of Sciences
  • 29 December 2009
TLDR
This study provides insight into potential pathogenic mechanisms of schizophrenia and suggests that PV-ErbB4−/− mice may serve as a model in the study of this and relevant brain disorders.
Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse
TLDR
Evidence is presented, using Alzheimer's disease model mice deficient in neural exosome secretion due to lack of neutral sphingomyelinase-2 function, that ceramide-enriched exosomes exacerbate AD-related brain pathology by promoting the aggregation of Aβ.
Repeated Exposures to Subthreshold Doses of Chlorpyrifos in Rats: Hippocampal Damage, Impaired Axonal Transport, and Deficits in Spatial Learning
TLDR
Results indicate that repeated exposures to subthreshold doses of CPF may lead to growth retardation, behavioral abnormalities, and muscle weakness, and some of these symptoms may be attributed to effects of the OP on axonal transport.
RG3487, a Novel Nicotinic α7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents
TLDR
RG3487 is a novel and potent α7nAChR partial agonist that improves cognitive performance and sensorimotor gating and exhibits antagonist properties at the serotonin 3 receptor.
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