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Experimental validation of miRNA targets.
The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development
Cholinergic abnormalities may also contribute to noncognitive behavioral abnormalities as well as the deposition of toxic neuritic plaques in AD and cholinergic-based strategies will likely remain valid as one approach to rational drug development for the treatment of AD other forms of dementia.
Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons
- Lei Wen, Yisheng Lu, L. Mei
- Biology, PsychologyProceedings of the National Academy of Sciences
- 29 December 2009
This study provides insight into potential pathogenic mechanisms of schizophrenia and suggests that PV-ErbB4−/− mice may serve as a model in the study of this and relevant brain disorders.
Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse
Evidence is presented, using Alzheimer's disease model mice deficient in neural exosome secretion due to lack of neutral sphingomyelinase-2 function, that ceramide-enriched exosomes exacerbate AD-related brain pathology by promoting the aggregation of Aβ.
Positive allosteric modulator of alpha 7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates
Repeated Exposures to Subthreshold Doses of Chlorpyrifos in Rats: Hippocampal Damage, Impaired Axonal Transport, and Deficits in Spatial Learning
- A. Terry, J. Stone, J. Buccafusco, D. W. Sickles, A. Sood, M. Prendergast
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 April 2003
Results indicate that repeated exposures to subthreshold doses of CPF may lead to growth retardation, behavioral abnormalities, and muscle weakness, and some of these symptoms may be attributed to effects of the OP on axonal transport.
Functional consequences of repeated organophosphate exposure: potential non-cholinergic mechanisms.
- A. Terry
- BiologyPharmacology & therapeutics
- 1 June 2012
RG3487, a Novel Nicotinic α7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents
- T. Wallace, P. Callahan, D. Lowe
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 January 2011
RG3487 is a novel and potent α7nAChR partial agonist that improves cognitive performance and sensorimotor gating and exhibits antagonist properties at the serotonin 3 receptor.
Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts.