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Is the forced swimming test a suitable model for revealing antidepressant activity?
This test appears to be suitable for detecting antidepressant activity in rats but not in mice, and difference in experimental procedure may account for the different sensitivity to drugs of the two animal species.
Do animal models of anxiety predict anxiolytic-like effects of antidepressants?
It is found that only the isolation-induced calls in guinea-pig pups may reveal anxiolytic-like action of all antidepressant classes after acute administration, and the predictive validity of models of "anxiety", such as the plus-maze and light–dark transition tests or stress-induced hyperthermia, appears to be limited to BDZ-related drugs.
BIMG 80, a Novel Potential Antipsychotic Drug: Evidence for Multireceptor Actions and Preferential Release of Dopamine in Prefrontal Cortex
- M. Volonté, E. Monferini, M. Cerutti, F. Fodritto, F. Borsini
- Psychology, MedicineJournal of neurochemistry
- 1 July 1997
BIMG 80 appears to be a potential antipsychotic compound active on negative symptoms of schizophrenia with a low incidence of extrapyramidal side effects.
Role of the serotonergic system in the forced swimming test
- F. Borsini
- Medicine, PsychologyNeuroscience & Biobehavioral Reviews
- 1 September 1995
The 5-HT system does not play a tonic role in animals performing the forced swimming test and the involvement of possible brain regions mediating the anti-immobility effects of 5- HT mimetic drugs has been discussed.
Animal models of depression in drug discovery: A historical perspective
This essay traces the origins and theoretical bases of the animal models of depression or depressed-like behaviours in humans and indicates how they have evolved from behavioural assays used to measure the potency and efficacy of potential candidate drugs to tools by which endophenotypes of depression may be identified and verified pharmacologically.
Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats.
Assessment of effects of the new preferential adenosine A2A receptor antagonist ST1535 in unilaterally 6-hydroxydopamine lesioned rats showed antiparkinsonian activity similar to that produced by a full dose of L-DOPA without exacerbating abnormal motor side effects, and it proved capable of reducing jaw tremors in tacrine model of Parkinson's disease tremor.
The Distinct Role of Medium Spiny Neurons and Cholinergic Interneurons in the D2/A2A Receptor Interaction in the Striatum: Implications for Parkinson's Disease
- A. Tozzi, Antonio de Iure, +8 authors P. Calabresi
- Biology, MedicineThe Journal of Neuroscience
- 2 February 2011
Evidence supports the hypothesis that striatal cholinergic interneurons, projecting to virtually all MSN subtypes, are involved in the D2/A2A and endocannabinoid-mediated effects observed on both subpopulations of MSNs in physiological conditions and in experimental PD.
Enol Carbamates as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) Endowed with High Selectivity for FAAH over the Other Targets of the Endocannabinoid System
Enol Carbamates as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) Endowed with High Selectivity for FAAH over the Other Targets of the Endocannabinoid System Sonia Gattinoni, Chiara De Simone, c]…
Effect of antipsychotic drugs and selective dopaminergic antagonists on dopamine-induced facilitatory activity in prelimbic cortical pyramidal neurons. An in vitro study
- A. Ceci, A. Brambilla, P. Duranti, M. Grauert, N. Grippa, F. Borsini
- Chemistry, MedicineNeuroscience
- 1 June 1999
Evidence is provided that dopamine has a facilitatory effect specifically on pyramidal neurons localized in the middle layer of prelimbic cortex, and an additive effect when co-administered with dopamine.