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Tacrine Hydrochloride

Known as: 1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride Monohydrate, Hydroaminacrine, Tacrine Hydrochloride [Chemical/Ingredient] 
The hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not… 
National Institutes of Health

Related topics

Related topics

5 relations
AcridinesAlzheimer's DiseaseDrug toxicityHypersensitivity

Papers overview

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2012
2012
Solid-state characterization of tacrine hydrochloride.
2009
2009
The action of hydroaminacrine and some other acridine compounds on isolated guinea-pig ileum.
2005
2005
Factorial design approach to evaluate interactions between electrically assisted enhancement and skin stripping for delivery of tacrine.
2004
2004
Synthesis and Characterization of 9-[P-(N, N-dipropyl Sulfamide)] Benzoylamino-1,2,3,4-4H-acridine—A Potential Prodrug for the CNS Delivery of Tacrine
9-[P-(N,N-dipropylsulfamide)]benzoylamino-1,2,3,4-4H-acridine (PTHA) was synthesized as a prodrug to improve the curative effect… 
1997
1997
Metabolic disposition of the cognition activator tacrine in rats, dogs, and humans. Species comparisons.
The metabolic fate of tacrine [1,2,3,4-tetrahydro-9-acridinamine monohydrochloride monohydrate (THA)] was examined in rats, dogs… 
1996
1996
The use of survival analysis techniques in evaluating the effect of long-term tacrine (Cognex) treatment on nursing home placement and mortality in patients with Alzheimer's disease.
Survival analysis techniques using Cox proportional hazards regressions with time-dependent covariates, life table survival plots… 
1996
1996
Liver Reactions to Tacrine
Alzheimer’s disease (AD) is a clinically debilitating dementia associated with various stages of memory dysfunction leading… 
1996
1996
Use of tacrine hydrochloride (Cognex®) in private practice
Before administering tacrine hydrochloride (Cognex®), an examination is conducted that includes a medical history, neurological… 
1996
1996
Variability in the plasma protein binding of velnacrine (1-hydroxy tacrine hydrochloride) A potential agent for Alzheimer’s disease
Abstract.Objectives: To quantify the protein binding of velnacrine in healthy individuals and investigate potential sources of… 
1992
1992
Serum levels of tacrine in relation to clinical response in Alzheimer's disease
The relationship between the serum concentrations of tacrine (tetrahydroaminoacridine), two of its metabolites and age, sex and… 
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