Tacrine Hydrochloride

Known as: 1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride Monohydrate, Hydroaminacrine, Tacrine Hydrochloride [Chemical/Ingredient] 
The hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1961-2016
024619612016

Papers overview

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2015
2015
Freshly excised rat skin and side-by-side permeation cells were used to study the effect of electronic and formulation variables… (More)
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2014
2014
The purpose of this study was the development of multifunctional liposomes for nasal administration of tacrine hydrochloride… (More)
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2011
2011
Peroral administration of tacrine, the first acetylcholinestearse inhibitor licensed for the treatment of Alzheimer's disease, is… (More)
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1996
1996
  • S I Gracon
  • Acta neurologica Scandinavica. Supplementum
  • 1996
The efficacy of tacrine hydrochloride (Cognex) for the treatment of Alzheimer's disease (AD) has been confirmed in two randomized… (More)
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Highly Cited
1994
Highly Cited
1994
OBJECTIVE To evaluate the efficacy and safety of high-dose tacrine hydrochloride over 30 weeks in patients with probable… (More)
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1994
1994
The aim of this study was to characterise the plasma protein binding of tacrine hydrochloride (THA) in vitro. Binding was… (More)
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1993
1993
OBJECTIVE To assess the value of serum measurements of tacrine hydrochloride and its metabolite in predicting risk of adverse… (More)
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Highly Cited
1992
Highly Cited
1992
OBJECTIVE To compare efficacy and safety of tacrine hydrochloride with placebo in patients with probable Alzheimer's disease… (More)
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Highly Cited
1992
Highly Cited
1992
BACKGROUND In Alzheimer's disease, there is a marked decline in the function of cholinergic neurons in the brain. However… (More)
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1989
1989
The clinical pharmacokinetics of tacrine hydrochloride have been characterized in patients who have Alzheimer's disease. Serum… (More)
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