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Tacrine Hydrochloride

Known as: 1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride Monohydrate, Hydroaminacrine, Tacrine Hydrochloride [Chemical/Ingredient] 
The hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Peroral administration of tacrine, the first acetylcholinestearse inhibitor licensed for the treatment of Alzheimer's disease, is… Expand
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Review
2000
Review
2000
Alzheimer disease (AD) involves neuronal degeneration with impaired cholinergic transmission in the cerebral cortex and… Expand
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1997
1997
OBJECTIVE To examine the effects of tacrine hydrochloride in patients with Alzheimer disease (AD) and detectable baseline… Expand
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Highly Cited
1994
Highly Cited
1994
Objective. —To evaluate the efficacy and safety of high-dose tacrine hydrochloride over 30 weeks in patients with probable… Expand
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Highly Cited
1994
Highly Cited
1994
OBJECTIVE To evaluate the efficacy and safety of high-dose tacrine hydrochloride over 30 weeks in patients with probable… Expand
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1994
1994
To the Editor. —The 30-week study of tacrine hydrochloride by Dr Knapp and colleagues 1 was the most edifying report yet… Expand
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Highly Cited
1992
Highly Cited
1992
Abstract Background. In Alzheimer's disease, there is a marked decline in the function of cholinergic neurons in the brain… Expand
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Highly Cited
1992
Highly Cited
1992
OBJECTIVE To compare efficacy and safety of tacrine hydrochloride with placebo in patients with probable Alzheimer's disease… Expand
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1992
1992
BACKGROUND In Alzheimer's disease, there is a marked decline in the function of cholinergic neurons in the brain. However… Expand
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1989
1989
The clinical pharmacokinetics of tacrine hydrochloride have been characterized in patients who have Alzheimer's disease. Serum… Expand
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