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Tacrine Hydrochloride

Known as: 1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride Monohydrate, Hydroaminacrine, Tacrine Hydrochloride [Chemical/Ingredient] 
The hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1961-2016
024619612016

Related topics

Related topics

5 relations
AcridinesAlzheimer's DiseaseDrug toxicityHypersensitivity

Broader (1)

Tacrine

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Tacrine Hydrochloride
Alzheimer's Disease
Hypersensitivity
Acridines
Drug toxicity
Tacrine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Influence of electronic and formulation variables on transdermal iontophoresis of tacrine hydrochloride.
Freshly excised rat skin and side-by-side permeation cells were used to study the effect of electronic and formulation variables… (More)
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2014
2014
Multifunctional liposomes for nasal delivery of the anti-Alzheimer drug tacrine hydrochloride.
The purpose of this study was the development of multifunctional liposomes for nasal administration of tacrine hydrochloride… (More)
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2011
2011
Albumin nanoparticles carrying cyclodextrins for nasal delivery of the anti-Alzheimer drug tacrine.
Peroral administration of tacrine, the first acetylcholinestearse inhibitor licensed for the treatment of Alzheimer's disease, is… (More)
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1996
1996
Evaluation of tacrine hydrochloride (Cognex) in two parallel-group studies.
  • S I Gracon
  • Acta neurologica Scandinavica. Supplementum
  • 1996
The efficacy of tacrine hydrochloride (Cognex) for the treatment of Alzheimer's disease (AD) has been confirmed in two randomized… (More)
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Highly Cited
1994
Highly Cited
1994
A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group.
OBJECTIVE To evaluate the efficacy and safety of high-dose tacrine hydrochloride over 30 weeks in patients with probable… (More)
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1994
1994
Characteristics of plasma protein binding of tacrine hydrochloride: a new drug for Alzheimer's disease
The aim of this study was to characterise the plasma protein binding of tacrine hydrochloride (THA) in vitro. Binding was… (More)
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1993
1993
Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's disease.
OBJECTIVE To assess the value of serum measurements of tacrine hydrochloride and its metabolite in predicting risk of adverse… (More)
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Highly Cited
1992
Highly Cited
1992
A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study Group.
OBJECTIVE To compare efficacy and safety of tacrine hydrochloride with placebo in patients with probable Alzheimer's disease… (More)
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Highly Cited
1992
Highly Cited
1992
A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group.
BACKGROUND In Alzheimer's disease, there is a marked decline in the function of cholinergic neurons in the brain. However… (More)
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1989
1989
Pharmacokinetics of tacrine hydrochloride in Alzheimer's disease.
The clinical pharmacokinetics of tacrine hydrochloride have been characterized in patients who have Alzheimer's disease. Serum… (More)
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