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Tacrine Hydrochloride
Known as:
1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride Monohydrate
, Hydroaminacrine
, Tacrine Hydrochloride [Chemical/Ingredient]
The hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not…
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National Institutes of Health
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Related topics
Related topics
5 relations
Acridines
Alzheimer's Disease
Drug toxicity
Hypersensitivity
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Albumin nanoparticles carrying cyclodextrins for nasal delivery of the anti-Alzheimer drug tacrine.
B. Luppi
,
F. Bigucci
,
+6 authors
V. Zecchi
European journal of pharmaceutical sciences…
2011
Corpus ID: 1515833
Review
1998
Review
1998
Cholinesterase inhibition for Alzheimer disease: a meta-analysis of the tacrine trials. Dementia Trialists' Collaboration.
N. Qizilbash
,
A. Whitehead
,
J. Higgins
,
G. Wilcock
,
L. Schneider
,
M. Farlow
JAMA
1998
Corpus ID: 24702714
OBJECTIVES To determine the effects of cholinesterase inhibition with tacrine hydrochloride for the symptoms of Alzheimer disease…
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Highly Cited
1997
Highly Cited
1997
Effect of tacrine on language, praxis, and noncognitive behavioral problems in Alzheimer disease.
M. Raskind
,
C. Sadowsky
,
W. Sigmund
,
P. Beitler
,
S. Auster
Archives of neurology
1997
Corpus ID: 12021760
OBJECTIVE To examine the effects of tacrine hydrochloride in patients with Alzheimer disease (AD) and detectable baseline…
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Highly Cited
1994
Highly Cited
1994
A 30-Week Randomized Controlled Trial of High-Dose Tacrine in Patients With Alzheimer's Disease
M. J. Knapp
,
D. Knopman
,
+97 authors
C. K. Kelley
1994
Corpus ID: 73162819
Objective. —To evaluate the efficacy and safety of high-dose tacrine hydrochloride over 30 weeks in patients with probable…
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Highly Cited
1994
Highly Cited
1994
A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group.
M. J. Knapp
,
D. Knopman
,
P. Solomon
,
W. Pendlebury
,
C. Davis
,
S. Gracon
JAMA
1994
Corpus ID: 33128505
OBJECTIVE To evaluate the efficacy and safety of high-dose tacrine hydrochloride over 30 weeks in patients with probable…
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Highly Cited
1994
Highly Cited
1994
Tacrine for Alzheimer's disease.
D. Riesenberg
,
N. Oakley
JAMA
1994
Corpus ID: 5095382
To the Editor. —The 30-week study of tacrine hydrochloride by Dr Knapp and colleagues 1 was the most edifying report yet…
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Highly Cited
1993
Highly Cited
1993
Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's disease
J. Ford
,
C. Truman
,
G. Wilcock
,
C. Roberts
Clinical pharmacology and therapeutics
1993
Corpus ID: 22858764
To assess the value of serum measurements of tacrine hydrochloride and its metabolite in predicting risk of adverse reaction in…
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Highly Cited
1993
Highly Cited
1993
Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species difference.
T. Woolf
,
W. Pool
,
+6 authors
W. Trager
Drug metabolism and disposition: the biological…
1993
Corpus ID: 11996058
Tacrine's [1,2,3,4-tetrahydro-9-acridinamine monohydrochloride monohydrate, (THA)] metabolic fate was examined using human and…
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Highly Cited
1992
Highly Cited
1992
A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group.
K. Davis
,
L. Thal
,
+7 authors
T. Hoover
The New England journal of medicine
1992
Corpus ID: 37075846
BACKGROUND In Alzheimer's disease, there is a marked decline in the function of cholinergic neurons in the brain. However…
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Highly Cited
1989
Highly Cited
1989
Pharmacokinetics of tacrine hydrochloride in Alzheimer's disease
D. Forsyth
,
G. Wilcock
,
R. Morgan
,
C. Truman
,
J. Ford
,
C. Roberts
Clinical pharmacology and therapeutics
1989
Corpus ID: 31273276
The clinical pharmacokinetics of tacrine hydrochloride have been characterized in patients who have Alzheimer's disease. Serum…
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