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Tacrine Hydrochloride

Known as: 1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride Monohydrate, Hydroaminacrine, Tacrine Hydrochloride [Chemical/Ingredient] 
The hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not… Expand
National Institutes of Health

Related topics

Related topics

5 relations
AcridinesAlzheimer's DiseaseDrug toxicityHypersensitivity
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Albumin nanoparticles carrying cyclodextrins for nasal delivery of the anti-Alzheimer drug tacrine.
Peroral administration of tacrine, the first acetylcholinestearse inhibitor licensed for the treatment of Alzheimer's disease, is… Expand
Review
1998
Review
1998
Cholinesterase inhibition for Alzheimer disease: a meta-analysis of the tacrine trials. Dementia Trialists' Collaboration.
OBJECTIVES To determine the effects of cholinesterase inhibition with tacrine hydrochloride for the symptoms of Alzheimer disease… Expand
Highly Cited
1997
Highly Cited
1997
Effect of tacrine on language, praxis, and noncognitive behavioral problems in Alzheimer disease.
OBJECTIVE To examine the effects of tacrine hydrochloride in patients with Alzheimer disease (AD) and detectable baseline… Expand
Highly Cited
1994
Highly Cited
1994
A 30-Week Randomized Controlled Trial of High-Dose Tacrine in Patients With Alzheimer's Disease
Objective. —To evaluate the efficacy and safety of high-dose tacrine hydrochloride over 30 weeks in patients with probable… Expand
Highly Cited
1994
Highly Cited
1994
A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group.
OBJECTIVE To evaluate the efficacy and safety of high-dose tacrine hydrochloride over 30 weeks in patients with probable… Expand
Highly Cited
1994
Highly Cited
1994
Tacrine for Alzheimer's disease.
Highly Cited
1993
Highly Cited
1993
Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's disease
To assess the value of serum measurements of tacrine hydrochloride and its metabolite in predicting risk of adverse reaction in… Expand
Highly Cited
1992
Highly Cited
1992
A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study Group.
OBJECTIVE To compare efficacy and safety of tacrine hydrochloride with placebo in patients with probable Alzheimer's disease… Expand
Highly Cited
1992
Highly Cited
1992
A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group.
BACKGROUND In Alzheimer's disease, there is a marked decline in the function of cholinergic neurons in the brain. However… Expand
Highly Cited
1989
Highly Cited
1989
Pharmacokinetics of tacrine hydrochloride in Alzheimer's disease
The clinical pharmacokinetics of tacrine hydrochloride have been characterized in patients who have Alzheimer's disease. Serum… Expand
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