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Tacrine Hydrochloride

Known as: 1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride Monohydrate, Hydroaminacrine, Tacrine Hydrochloride [Chemical/Ingredient] 
The hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not… 
National Institutes of Health

Related topics

Related topics

5 relations
AcridinesAlzheimer's DiseaseDrug toxicityHypersensitivity

Papers overview

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Highly Cited
2011
Highly Cited
2011
Albumin nanoparticles carrying cyclodextrins for nasal delivery of the anti-Alzheimer drug tacrine.
Review
1998
Review
1998
Cholinesterase inhibition for Alzheimer disease: a meta-analysis of the tacrine trials. Dementia Trialists' Collaboration.
OBJECTIVES To determine the effects of cholinesterase inhibition with tacrine hydrochloride for the symptoms of Alzheimer disease… 
Highly Cited
1997
Highly Cited
1997
Effect of tacrine on language, praxis, and noncognitive behavioral problems in Alzheimer disease.
OBJECTIVE To examine the effects of tacrine hydrochloride in patients with Alzheimer disease (AD) and detectable baseline… 
Highly Cited
1994
Highly Cited
1994
A 30-Week Randomized Controlled Trial of High-Dose Tacrine in Patients With Alzheimer's Disease
Objective. —To evaluate the efficacy and safety of high-dose tacrine hydrochloride over 30 weeks in patients with probable… 
Highly Cited
1994
Highly Cited
1994
A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group.
OBJECTIVE To evaluate the efficacy and safety of high-dose tacrine hydrochloride over 30 weeks in patients with probable… 
Highly Cited
1994
Highly Cited
1994
Tacrine for Alzheimer's disease.
To the Editor. —The 30-week study of tacrine hydrochloride by Dr Knapp and colleagues 1 was the most edifying report yet… 
Highly Cited
1993
Highly Cited
1993
Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's disease
To assess the value of serum measurements of tacrine hydrochloride and its metabolite in predicting risk of adverse reaction in… 
Highly Cited
1993
Highly Cited
1993
Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species difference.
Tacrine's [1,2,3,4-tetrahydro-9-acridinamine monohydrochloride monohydrate, (THA)] metabolic fate was examined using human and… 
Highly Cited
1992
Highly Cited
1992
A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group.
BACKGROUND In Alzheimer's disease, there is a marked decline in the function of cholinergic neurons in the brain. However… 
Highly Cited
1989
Highly Cited
1989
Pharmacokinetics of tacrine hydrochloride in Alzheimer's disease
The clinical pharmacokinetics of tacrine hydrochloride have been characterized in patients who have Alzheimer's disease. Serum… 
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