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Tacrine Hydrochloride

Known as: 1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride Monohydrate, Hydroaminacrine, Tacrine Hydrochloride [Chemical/Ingredient] 
The hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Peroral administration of tacrine, the first acetylcholinestearse inhibitor licensed for the treatment of Alzheimer's disease, is… Expand
Review
1998
Review
1998
OBJECTIVES To determine the effects of cholinesterase inhibition with tacrine hydrochloride for the symptoms of Alzheimer disease… Expand
Highly Cited
1997
Highly Cited
1997
OBJECTIVE To examine the effects of tacrine hydrochloride in patients with Alzheimer disease (AD) and detectable baseline… Expand
Highly Cited
1994
Highly Cited
1994
Objective. —To evaluate the efficacy and safety of high-dose tacrine hydrochloride over 30 weeks in patients with probable… Expand
Highly Cited
1994
Highly Cited
1994
OBJECTIVE To evaluate the efficacy and safety of high-dose tacrine hydrochloride over 30 weeks in patients with probable… Expand
Highly Cited
1994
Highly Cited
1994
Highly Cited
1993
Highly Cited
1993
To assess the value of serum measurements of tacrine hydrochloride and its metabolite in predicting risk of adverse reaction in… Expand
Highly Cited
1992
Highly Cited
1992
OBJECTIVE To compare efficacy and safety of tacrine hydrochloride with placebo in patients with probable Alzheimer's disease… Expand
Highly Cited
1992
Highly Cited
1992
BACKGROUND In Alzheimer's disease, there is a marked decline in the function of cholinergic neurons in the brain. However… Expand
Highly Cited
1989
Highly Cited
1989
The clinical pharmacokinetics of tacrine hydrochloride have been characterized in patients who have Alzheimer's disease. Serum… Expand