Skip to search formSkip to main contentSkip to account menu

TUSC2 gene

Known as: TUSC2, Tumor Suppressor Candidate 2 Gene, C3orf11 
This gene plays a putative role in apoptosis and the negative regulation of cell growth.
National Institutes of Health

Related topics

Related topics

8 relations
Cell Proliferation Regulatory ProcessHomo sapiensInhibition of Cancer Cell GrowthLung Neoplasms

Narrower (1)

TUSC2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
LncRNA GAS5-AS1 inhibits glioma proliferation, migration, and invasion via miR‐106b-5p/TUSC2 axis
Glioma is one of the most common malignant tumors and shows a high metastasis rate and poor prognosis. Abnormal expression of… 
2019
2019
MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression
Breast cancer manifests as a spectrum of subtypes with distinct molecular signatures, and different responses to treatment. Of… 
Review
2017
Review
2017
Tumor suppressor candidate 2 (TUSC2, FUS-1) and human cancers.
Tumor suppressor candidate 2 (TUSC2, also known as FUS1) was identified in 2000 as a candidate tumor suppressor gene located in a… 
2016
2016
TWIST1/miR-584/TUSC2 pathway induces resistance to apoptosis in thyroid cancer cells
TWIST1, a transcription factor, plays a pivotal role in cancer initiation and progression. Anaplastic thyroid carcinoma (ATC) is… 
2015
2015
Exogenous Restoration of TUSC2 Expression Induces Responsiveness to Erlotinib in Wildtype Epidermal Growth Factor Receptor (EGFR) Lung Cancer Cells through Context Specific Pathways Resulting in…
Expression of the tumor suppressor gene TUSC2 is reduced or absent in most lung cancers and is associated with worse overall… 
Highly Cited
2014
Highly Cited
2014
The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs
Various non-coding regions of the genome, once presumed to be ‘junk’ DNA, have recently been found to be transcriptionally active… 
2013
2013
The Tumor Suppressor Gene TUSC2 (FUS1) Sensitizes NSCLC to the AKT Inhibitor MK2206 in LKB1-dependent Manner
TUSC2-defective gene expression is detected in the majority of lung cancers and is associated with worse overall survival. We… 
2013
2013
Identification of guanine nucleotide-binding protein γ-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling
Silencing of tumor suppressor genes plays a vital role in head and neck carcinogenesis. Aberrant hypermethylation in the promoter… 
Highly Cited
2012
Highly Cited
2012
Phase I Clinical Trial of Systemically Administered TUSC2(FUS1)-Nanoparticles Mediating Functional Gene Transfer in Humans
Background Tumor suppressor gene TUSC2/FUS1 (TUSC2) is frequently inactivated early in lung cancer development. TUSC2 mediates… 
2011
2011
Different gene expression profiles in metastasizing midgut carcinoid tumors.
The genetic events leading the progression of midgut carcinoid tumors are largely unknown. The disease course varies from patient… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)