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TTR gene

Known as: Transthyretin Gene, PALB, TRANSTHYRETIN 
This gene is involved in both the binding and transport of retinol and the thyroid hormone thyroxine.
National Institutes of Health

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Related topics

7 relations
AmyloidosisHomo sapiensLigand BindingMetabolism

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TTR wt Allele

Papers overview

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Highly Cited
2007
Highly Cited
2007
Further Characterization of the Signaling Proteolysis Step in the Aspergillus nidulans pH Signal Transduction Pathway
ABSTRACT The Aspergillus nidulans pH-responsive transcription factor PacC is modulated by limited, two-step proteolysis. The… 
Highly Cited
2005
Highly Cited
2005
L55P Transthyretin Accelerates Subunit Exchange and Leads to Rapid Formation of Hybrid Tetramers*
Transthyretin is a tetrameric protein associated with the commonest form of systemic amyloid disease. Using isotopically labeled… 
Highly Cited
2000
Highly Cited
2000
Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface.
Transthyretin is a human protein capable of amyloid formation that is believed to cause several types of amyloid disease… 
Highly Cited
1998
Highly Cited
1998
The Crystal Structure of Amyloidogenic Leu55→ Pro Transthyretin Variant Reveals a Possible Pathway for Transthyretin Polymerization into Amyloid Fibrils*
The x-ray crystal structure of the amyloidogenic Leu55 → Pro transthyretin (TTR) variant, implicated as the causative agent in… 
Highly Cited
1997
Highly Cited
1997
Comparative stability and clearance of [Met30]transthyretin and [Met119]transthyretin.
[Met119]Transthyretin has been described as a non-amyloidogenic transthyretin variant. In Portugal, it has also been found in… 
Highly Cited
1996
Highly Cited
1996
A new simple and rapid screening method for variant transthyretin-related amyloidosis.
To screen for transthyretin (TTR) related amyloidosis rapidly and reliably, we have developed a new method using a centrifugal… 
Highly Cited
1994
Highly Cited
1994
Mechanism of molecular recognition. Structural aspects of 3,3'-diiodo-L-thyronine binding to human serum transthyretin.
The three-dimensional structure of the thyroid hormone metabolite, 3,3'-diiodo-L-thyronine (3,3'-T2), complex with human serum… 
Highly Cited
1993
Highly Cited
1993
X-ray crystal structure of the Ala-109-->Thr variant of human transthyretin which produces euthyroid hyperthyroxinemia.
Highly Cited
1990
Highly Cited
1990
Receptor-mediated uptake and internalization of transthyretin.
Highly Cited
1988
Highly Cited
1988
Study on the mechanism of interference of 3,4,3',4'-tetrachlorobiphenyl with the plasma retinol-binding proteins in rodents.
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