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TSC1 gene

Known as: LAM, tuberous sclerosis 1, Tuberous Sclerosis 1 Gene 
This gene is involved in cell cycle regulation and the loss of cellular adhesion.
National Institutes of Health

Related topics

Related topics

10 relations
Cell AdhesionCell Cycle ControlLigand BindingSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Tuberous Sclerosis 1 Promotes Invariant NKT Cell Anergy and Inhibits Invariant NKT Cell–Mediated Antitumor Immunity
Development of effective immune therapies for cancer patients requires better understanding of hurdles that prevent the… 
2007
2007
Cytoplasmic/nuclear localization of tuberin in different cell lines
Summary.Tuberous sclerosis (TSC) is an autosomal dominantly inherited disease affecting 1 in 6000 individuals. The TSC gene… 
Review
2006
Review
2006
The tuberous sclerosis genes and regulation of the cyclin-dependent kinase inhibitor p27.
2003
2003
Tuberous sclerosis-associated neoplasms express activated p42/44 mitogen-activated protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth.
PURPOSE Tuberous sclerosis (TS) is a common autosomal disorder attributable to inactivation of the tumor suppressor genes tuberin… 
Highly Cited
2003
Highly Cited
2003
14-3-3β Binds to and Negatively Regulates the Tuberous Sclerosis Complex 2 (TSC2) Tumor Suppressor Gene Product, Tuberin*
TSC2, or tuberin, is the product of the tuberous sclerosis tumor suppressor gene TSC2 and acts downstream of the… 
2002
2002
Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin.
2000
2000
A new member of an old family
A newly discovered platelet-derived growth factor (PDGF) isoform, PDGF-CC, is expressed in the mouse kidney during development… 
2000
2000
Analysis of all exons of TSC1 and TSC2 genes for germline mutations in Japanese patients with tuberous sclerosis: report of 10 mutations.
Twenty-seven Japanese patients with the tuberous sclerosis complex (TSC), consisting of 23 sporadic and 4 familial cases, were… 
1998
1998
Comprehensive mutation analysis of TSC1 using two‐dimensional DNA electrophoresis with DGGE
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterised by the development of benign tumors in multiple… 
Highly Cited
1998
Highly Cited
1998
New insights into the tumor suppression function of P27Kip1
Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by mental retardation, seizures, and tumors… 
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