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TREX1 protein, human

Known as: TREX1, 3' Repair Exonuclease 1, 3'-5' Exonuclease TREX1 
Three prime repair exonuclease 1 (369 aa, ~39 kDa) is encoded by the human TREX1 gene. This protein is involved in DNA mismatch repair.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
TREX1 is an endoplasmic reticulum (ER)-associated negative regulator of innate immunity. TREX1 mutations are associated with… Expand
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2015
2015
IMPORTANCE Familial chilblain lupus is a rare, autosomal dominant form of lupus erythematosus characterized by cold-induced… Expand
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Highly Cited
2014
Highly Cited
2014
Cytosolic detection of DNA is crucial for the initiation of antiviral immunity but can also cause autoimmunity in the context of… Expand
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2014
2014
AbstractRetinal vasculopathy with cerebral leukodystrophy (RVCL) is an adult-onset disorder caused by C-terminal heterozygous… Expand
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Highly Cited
2013
Highly Cited
2013
Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE… Expand
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Highly Cited
2012
Highly Cited
2012
The type I interferon (IFN) response initiated by detection of nucleic acids is important for antiviral defense but is also… Expand
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Highly Cited
2010
Highly Cited
2010
A variety of small RNAs, including the Dicer-dependent miRNAs and the Dicer-independent Piwi-interacting RNAs, associate with… Expand
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Highly Cited
2008
Highly Cited
2008
Detection of nucleic acids and induction of type I interferons (IFNs) are principal elements of antiviral defense but can cause… Expand
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2007
2007
TREX1 is the most abundant mammalian 3′ → 5′ DNA exonuclease. It has been described to form part of the SET complex and is… Expand
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Highly Cited
2001
Highly Cited
2001
The excision of nucleotides from DNA 3′ termini is an important step in DNA replication, repair, and recombination pathways to… Expand