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TREX1 protein, human

Known as: TREX1, 3' Repair Exonuclease 1, 3'-5' Exonuclease TREX1 
Three prime repair exonuclease 1 (369 aa, ~39 kDa) is encoded by the human TREX1 gene. This protein is involved in DNA mismatch repair.
National Institutes of Health

Related topics

Related topics

14 relations
3'-5'-ExonucleasesDNA RepairDNA Repair GeneDNA Replication

Broader (1)

Three Prime Repair Exonuclease 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Assessment of Clinical Response to Janus Kinase Inhibition in Patients With Familial Chilblain Lupus and TREX1 Mutation
Importance Familial chilblain lupus is a monogenic autosomal dominant form of cutaneous lupus erythematosus that in most cases is… 
2019
2019
TREX1 as a potential therapeutic target for autoimmune and inflammatory diseases.
The 3' repair exonuclease 1 (TREX1) gene is the major DNA-specific 3'-5 'exonuclease of mammalian cells which reduces single- and… 
2018
2018
TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia
Mutations in the three‐prime repair exonuclease 1 (TREX1) gene have been associated with neurological diseases, including Retinal… 
2018
2018
Rad6-Bre1 mediated histone H2Bub1 protects uncapped telomeres from exonuclease Exo1 in Saccharomyces cerevisiae.
2017
2017
An ultrasensitive conformation-dependent colorimetric probe for the detection of mercury(II) using exonuclease III-assisted target recycling and gold nanoparticles
AbstractAn ultrasensitive conformation-dependent colorimetric assay has been developed for the detection of mercury(II) ions. It… 
Highly Cited
2016
Highly Cited
2016
MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
Rather than targeting tumour cells directly, elements of the tumour microenvironment can be modulated to sensitize tumours to the… 
2014
2014
TLR ligands up‐regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF‐κB‐dependent signaling pathways
Mutations in the Trex1 are associated with a spectrum of type I IFN‐dependent autoimmune diseases. Trex1 plays an essential role… 
Review
2014
Review
2014
Clearance of endogenous L1 retroelements in the cytosol by TREX1 prevents neuronal toxicity
Author(s): Thomas, Charles Austin | Advisor(s): Muotri, Alysson R | Abstract: This Dissertation is broken into four chapters. In… 
2009
2009
TREX1 acts in degrading damaged DNA from drug-treated tumor cells.
1998
1998
Lethality of high linear energy transfer cosmic radiation to Escherichia coli DNA repair-deficient mutants during the 'SL-J/FMPT' space experiment.
We investigated the lethal and mutagenic effects of high linear energy transfer cosmic radiation on 11 strains of Escherichia… 
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