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TREX1 protein, human

Known as: TREX1, 3' Repair Exonuclease 1, 3'-5' Exonuclease TREX1 
Three prime repair exonuclease 1 (369 aa, ~39 kDa) is encoded by the human TREX1 gene. This protein is involved in DNA mismatch repair.
National Institutes of Health

Related topics

Related topics

14 relations
3'-5'-ExonucleasesDNA RepairDNA Repair GeneDNA Replication

Broader (1)

Three Prime Repair Exonuclease 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Assessment of Clinical Response to Janus Kinase Inhibition in Patients With Familial Chilblain Lupus and TREX1 Mutation
Importance Familial chilblain lupus is a monogenic autosomal dominant form of cutaneous lupus erythematosus that in most cases is… 
2018
2018
TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia
Mutations in the three‐prime repair exonuclease 1 (TREX1) gene have been associated with neurological diseases, including Retinal… 
Highly Cited
2016
Highly Cited
2016
Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity
Defects of the intracellular enzyme 3′ repair exonuclease 1 (Trex1) cause the rare autoimmune condition Aicardi–Goutières… 
Highly Cited
2015
Highly Cited
2015
Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.
2015
2015
Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA*
Background: 3′ repair exonuclease 1 (TREX1) is a DNase involved in autoimmune disorders and the antiviral response. Results… 
2014
2014
The 3′–5′ DNA Exonuclease TREX1 Directly Interacts with Poly(ADP-ribose) Polymerase-1 (PARP1) during the DNA Damage Response*
Background: TREX1 is a 3′–5′ DNA exonuclease, and mutations in human TREX1 are associated with autoimmune/inflammatory diseases… 
2014
2014
Association of nuclear annexin A1 with prognosis of patients with esophageal squamous cell carcinoma.
Although recent progress has been made in the diagnosis and treatment of cancer, the prognosis of esophageal squamous cell… 
Highly Cited
2009
Highly Cited
2009
Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease.
The major DNA-specific 3'-5' exonuclease of mammalian cells is TREX1 (3' repair exonuclease 1; previously called DNase III). The… 
2009
2009
TREX1 acts in degrading damaged DNA from drug-treated tumor cells.
2007
2007
Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1
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