TRAF6 gene

Known as: TNF RECEPTOR-ASSOCIATED FACTOR 6, TRAF6, TNF Receptor-Associated Factor 6 Gene 
This gene plays a role in signal transduction and regulation of apoptosis. It is also involved in the immune response and bone homeostasis.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Autophagy is important in the basal or stress-induced clearance of bulk cytosol, damaged organelles, pathogens and selected… (More)
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Highly Cited
2009
Highly Cited
2009
Akt signaling plays a central role in many biological functions, such as cell proliferation and apoptosis. Because Akt (also… (More)
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Highly Cited
2009
Highly Cited
2009
CD8 T cells, which have a crucial role in immunity to infection and cancer, are maintained in constant numbers, but on antigen… (More)
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Highly Cited
2009
Highly Cited
2009
Toll/interleukin-1 (TIR)receptor-containing adapters are critical in orchestrating the different signal transduction pathways… (More)
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Highly Cited
2008
Highly Cited
2008
The adapter protein TRAF6 is critical for mediating signal transduction from members of the IL-1R/TLR and TNFR superfamilies. The… (More)
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Highly Cited
2006
Highly Cited
2006
TRAF6 has a key role in the regulation of innate immune responses by mediating signals from both TNF receptor and interleukin-1… (More)
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Highly Cited
2005
Highly Cited
2005
RANK and CD40 activate NF-kappaB and MAPKs to similar levels via TRAF6. Even though overexpression of TRAF6 results in osteoclast… (More)
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Highly Cited
2002
Highly Cited
2002
The receptor activator of NF-kappaB (RANK) and its ligand RANKL are key molecules for differentiation and activation of… (More)
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Highly Cited
2000
Highly Cited
2000
TRAF6 is a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory… (More)
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Highly Cited
1998
Highly Cited
1998
Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE), a member of the TNF family expressed on activated T… (More)
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