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TRAF6 gene

Known as: TNF RECEPTOR-ASSOCIATED FACTOR 6, TRAF6, TNF Receptor-Associated Factor 6 Gene 
This gene plays a role in signal transduction and regulation of apoptosis. It is also involved in the immune response and bone homeostasis.
National Institutes of Health

Related topics

Related topics

5 relations
Signal TransductionTNF receptor-associated factor 6Ubiquitinationinflammatory response

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Characterization of the black carp TRAF6 signaling molecule in innate immune defense
2017
2017
Combined TRAF6 Targeting and Proteasome Blockade Has Anti-myeloma and Anti-Bone Resorptive Effects
TNF receptor–associated factor 6 (TRAF6) has been implicated in polyubiquitin-mediated IL1R/TLR signaling through activation of I… 
Highly Cited
2016
Highly Cited
2016
TRAF6 regulates melanoma invasion and metastasis through ubiquitination of Basigin
TRAF6 plays a crucial role in the regulation of the innate and adaptive immune responses. Although studies have shown that TRAF6… 
2016
2016
NF-κB is involved in the LPS-mediated proliferation and apoptosis of MAC-T epithelial cells as part of the subacute ruminal acidosis response in cows
ObjectivesTo determine the effect of NF-κB on cell proliferation and apoptosis, we investigate the expression of inflammation and… 
2015
2015
Molecular genomic- and transcriptional-aspects of a teleost TRAF6 homolog: Possible involvement in immune responses of Oplegnathus fasciatus against pathogens.
2010
2010
Roles of TRAF2 and TRAF3 in Epstein-Barr virus latent membrane protein 1-induced alternative NF-κB activation
Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1)-induced NF-κB activation is essential for EBV-transformed B cell… 
2009
2009
Polymorphisms in interleukin‐1 receptor‐associated kinase 4 are associated with total serum IgE
Background:  Serum immunoglobulin E (IgE) level is recognized to be under strong genetic control, but the causal and… 
Highly Cited
2008
Highly Cited
2008
The Protein Kinase C-Responsive Inhibitory Domain of CARD11 Functions in NF-κB Activation To Regulate the Association of Multiple Signaling Cofactors That Differentially Depend on Bcl10 and MALT1 for…
ABSTRACT The activation of NF-κB by T-cell receptor (TCR) signaling is critical for T-cell activation during the adaptive immune… 
2005
2005
Hyper-IgE syndrome is not associated with defects in several candidate toll-like receptor pathway genes.
2004
2004
Interactions among human immunodeficiency virus (HIV)-1, interferon-gamma and receptor of activated NF-kappa B ligand (RANKL): implications for HIV pathogenesis.
We reported recently that exposure of human T cells to soluble HIV-1 envelope glycoprotein gp120 induced biologically active… 
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