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TNF receptor-associated factor 6

Known as: TNF Receptor Associated Factor 6, TRAF6, TRAF 6 Protein 
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas, human TRAF6 Gene (TRAF Family) encodes 522-aa 60-kDa… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Reactive oxygen species (ROS) are essential components of the innate immune response against intracellular bacteria and it is… Expand
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Highly Cited
2008
Highly Cited
2008
Although papillary thyroid carcinoma (PTC) displays strong heritability, no predisposing germ-line mutations have been found. We… Expand
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Highly Cited
2005
Highly Cited
2005
The activation of Toll-like receptors (TLRs) is central to innate and adaptive immunity. All TLRs use the adaptor MyD88 for… Expand
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Highly Cited
2005
Highly Cited
2005
Viral infection or stimulation of TLR3 triggers signaling cascades, leading to activation of the transcription factors IRF-3 and… Expand
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Highly Cited
2004
Highly Cited
2004
A20 is a cytoplasmic protein required for the termination of tumor necrosis factor (TNF)–induced signals. We show here that mice… Expand
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Highly Cited
2003
Highly Cited
2003
We previously reported a new Toll/IL-1R (TIR)-containing molecule, named TIR domain-containing adaptor inducing IFN-β (TRIF… Expand
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Highly Cited
2003
Highly Cited
2003
Familial cylindromatosis is an autosomal dominant predisposition to tumours of skin appendages called cylindromas. Familial… Expand
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Highly Cited
2002
Highly Cited
2002
Signaling by RANKL is essential for terminal differentiation of monocytes/macrophages into osteoclasts. The TRAF6 and c-Fos… Expand
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Highly Cited
2001
Highly Cited
2001
TRAF6 is a signal transducer that activates IκB kinase (IKK) and Jun amino-terminal kinase (JNK) in response to pro-inflammatory… Expand
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Highly Cited
2000
Highly Cited
2000
TRAF6 is a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory… Expand
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