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TP53AIP1 wt Allele

Known as: P53AIP1, Tumor Protein p53 Regulated Apoptosis Inducing Protein 1 wt Allele 
Human TP53AIP1 wild-type allele is located in the vicinity of 11q24.3 and is approximately 9 kb in length. This allele, which encodes p53-regulated… 
National Institutes of Health

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2 relations
Apoptosisp53 Signaling Pathway KEGG

Papers overview

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2012
2012
Altered Binding Site Selection of p53 Transcription Cassettes by Hepatitis B Virus X Protein
ABSTRACT The key cellular regulator p53 is a common target of viral oncoproteins. However, the mechanism by which p53… 
2010
2010
p53-mediated induction of Noxa and p53AIP1 requires NFkappaB.
The intricate regulation of cell survival and cell death is critical for the existence of both normal and transformed cells. Two… 
2009
2009
Combination of p53AIP1 and survivin expression is a powerful prognostic marker in non-small cell lung cancer
Backgroundp53AIP1 is a potential mediator of apoptosis depending on p53, which is mutated in many kinds of carcinoma. High… 
2007
2007
Prothymosin-α1 prevents necrosis and apoptosis following stroke
specificity for gene transcription and, in agreement with previous results, p21 was not upregulated. Furthermore, the involvement… 
2007
2007
Roscovitine‐activated HIP2 kinase induces phosphorylation of wt p53 at Ser‐46 in human MCF‐7 breast cancer cells
Human MCF‐7 breast cancer cells are relatively resistant to conventional chemotherapy due to the lack of caspase‐3 activity. We… 
2007
2007
In vivo evaluation of the role of DNp73α protein in regulating the p53‐dependent apoptotic pathway after treatment with cytotoxic drugs
The amino terminus truncated p73 isoform, ΔNp73α, shows dominant negative behavior toward TAp73 and wild‐type p53, and has… 
Review
2006
Review
2006
Arsenic trioxide in hematological malignancies: the new discovery of an ancient drug.
Currently, Arsenic Trioxide (ATO) is considered the treatment of choice for patients with relapsed acute promyelocytic leukemia… 
2006
2006
Truncating variants in p53AIP1 disrupting DNA damage-induced apoptosis are associated with prostate cancer risk.
Germ line mutations in several genes (BRCA1, BRCA2, and CHEK2) whose products are involved in the DNA damage-signaling pathway… 
Highly Cited
2005
Highly Cited
2005
Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells.
We reported recently that roscovitine arrested human MCF-7 cancer cells at G2-M phase of the cell cycle and concomitantly induced… 
2002
2002
p 53 AIP 1 Regulates the Mitochondrial Apoptotic Pathway 1
We identified recently the p53AIP1 gene, a novel p53 target that mediates p53-dependent apoptosis. In the experiments reported… 
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