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TOP2A gene

Known as: topo II alpha, Topoisomerase (DNA) II Alpha 170kDa Gene, TOP2A 
This gene plays a role in DNA replication, chromosome recombination and the regulation of DNA topology during transcription.
National Institutes of Health

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Related topics

8 relations
Chromosome CondensationDNA ReplicationDNA Topology RegulationDNA topoisomerase II alpha

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TOP2A wt Allele

Papers overview

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2019
2019
The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison
2,6-Diaminopyridine-3,5-bis(thiocyanate) (PR-619) is a broad-spectrum deubiquitinating enzyme (DUB) inhibitor that has been… 
2013
2013
Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-IIα by bis-DemethoxyCurcumin in cancer cells
Topoisomerases-IIα (TOP2A) enzyme is essential for cell viability due to its fundamental role in DNA metabolism and in chromatin… 
2011
2011
[Molecular determinants of response to topoisomerase II inhibitors].
Human nuclear topoisomerases II (Top2) are involved in the relaxation of DNA supercoiling during transcription and replication… 
2011
2011
HIV gene expression from intact proviruses positioned in bacterial artificial chromosomes at integration sites previously identified in latently infected T cells.
2007
2007
A Mouse Model for Studying the Interaction of Bisdioxopiperazines with Topoisomerase IIα in Vivo
The bisdioxopiperazines such as (+)-(S)-4,4′-propylenedi-2,6-piperazinedione (dexrazoxane; ICRF-187), 1,2-bis(3,5-dioxopiperazin… 
Highly Cited
2005
Highly Cited
2005
The incidence of topoisomerase II-alpha genomic alterations in adenocarcinoma of the breast and their relationship to human epidermal growth factor receptor-2 gene amplification: a fluorescence in…
2002
2002
CCAAT Binding Factor (CBF) Binding Mediates Cell Cycle Activation of Topoisomerase IIα
To understand the role of the CCAAT binding factor (CBF) in transcription during the cell cycle, we studied the mouse… 
2002
2002
Type II DNA Topoisomerase (Top2) as Promising Molecular Marker for Phylogenetic Analysis in Rhodophyta
Abstract Taxonomic uncertainty still exists in the Rhodophyta, and more suitable molecular markers for their phylogeny are… 
1992
1992
Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.
Human cells contain two topoisomerase II isozymes named topo II alpha and topo II beta. The complementary DNAs for both enzymes… 
1992
1992
Amplification of the topoisomerase II alpha gene in a non-small cell lung cancer cell line and characterisation of polymorphisms at the human topoisomerase II alpha and beta loci in normal tissue.
DNA was prepared from normal tissue and 19 lung cancer cell lines. Using probes which detect restriction fragment length… 
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