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TOP2A gene

Known as: topo II alpha, Topoisomerase (DNA) II Alpha 170kDa Gene, TOP2A 
This gene plays a role in DNA replication, chromosome recombination and the regulation of DNA topology during transcription.
National Institutes of Health

Related topics

Related topics

8 relations
Chromosome CondensationDNA ReplicationDNA Topology RegulationDNA topoisomerase II alpha

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TOP2A wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The resistance of esophageal cancer cells to paclitaxel can be reduced by the knockdown of long noncoding RNA DDX11-AS1 through TAF1/TOP2A inhibition.
Esophageal cancer (EC) is one of the most common malignancies in the world. The currently used chemotherapeutic drug for the… 
2019
2019
The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison
2,6-Diaminopyridine-3,5-bis(thiocyanate) (PR-619) is a broad-spectrum deubiquitinating enzyme (DUB) inhibitor that has been… 
2018
2018
MGMT inhibition in ER positive breast cancer leads to CDC2, TOP2A, AURKB, CDC20, KIF20A, Cyclin A2, Cyclin B2, Cyclin D1, ERα and Survivin inhibition and enhances response to temozolomide
The DNA damage repair enzyme, O6-methylguanine DNA methyltransferase (MGMT) is overexpressed in breast cancer, correlating… 
Highly Cited
2017
Highly Cited
2017
Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci
Type II topoisomerases orchestrate proper DNA topology, and they are the targets of anti-cancer drugs that cause treatment… 
2017
2017
FISH Analysis of TOP2A and HER-2 Aberrations in Female Breast Carcinoma on Archived Material: Egyptian NCI Experience
Background: HER-2 and TOP2A genes are considered of great importance in breast cancer. Their copy number variability has been… 
2013
2013
Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-IIα by bis-DemethoxyCurcumin in cancer cells
Topoisomerases-IIα (TOP2A) enzyme is essential for cell viability due to its fundamental role in DNA metabolism and in chromatin… 
2011
2011
[Molecular determinants of response to topoisomerase II inhibitors].
Human nuclear topoisomerases II (Top2) are involved in the relaxation of DNA supercoiling during transcription and replication… 
2002
2002
CCAAT Binding Factor (CBF) Binding Mediates Cell Cycle Activation of Topoisomerase IIα
To understand the role of the CCAAT binding factor (CBF) in transcription during the cell cycle, we studied the mouse… 
2002
2002
Type II DNA Topoisomerase (Top2) as Promising Molecular Marker for Phylogenetic Analysis in Rhodophyta
Abstract Taxonomic uncertainty still exists in the Rhodophyta, and more suitable molecular markers for their phylogeny are… 
Highly Cited
1994
Highly Cited
1994
Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection.
Fluctuation analysis experiments were performed in the human sarcoma cell line MES-SA to assess whether selection or induction… 
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