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Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme.
DNA topoisomerase I is essential for cellular metabolism and survival. It is also the target of a novel class of anticancer drugs active against previously refractory solid tumors, the camptothecins.Expand
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Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
While investigating the novel anticancer drug ecteinascidin 743 (Et743), a natural marine product isolated from the Caribbean sea squirt, we discovered a new cell-killing mechanism mediated by DNAExpand
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Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin
ABSTRACT This report demonstrates that Gadd45, a p53-responsive stress protein, can facilitate topoisomerase relaxing and cleavage activity in the presence of core histones. A correlation betweenExpand
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Epidemiology, molecular virology and diagnostics of Schmallenberg virus, an emerging orthobunyavirus in Europe
After the unexpected emergence of Bluetongue virus serotype 8 (BTV-8) in northern Europe in 2006, another arbovirus, Schmallenberg virus (SBV), emerged in Europe in 2011 causing a new economicallyExpand
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The DNA polymerase λ is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells
DNA polymerase lambda (polλ) is a recently identified DNA polymerase whose cellular function remains elusive. Here we show, that polλ participates at the molecular level in a chromosomal context, inExpand
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The chemistry of wine polyphenolic C-glycosidic ellagitannins targeting human topoisomerase II.
Polyphenolic nonahydroxyterphenoyl-containing C-glycosidic oak ellagitannins are found in wine as a result of the aging of this beverage in oak-made barrels. Once in the slightly acidic wine (pHExpand
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The Most Likely Time and Place of Introduction of BTV8 into Belgian Ruminants
Background In northern Europe, bluetongue (BT) caused by the BT virus (BTV), serotype 8, was first notified in August 2006 and numerous ruminant herds were affected in 2007 and 2008. However, theExpand
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Topoisomerase I-mediated DNA damage.
Topoisomerase I is a ubiquitous and essential enzyme in multicellular organisms. It is involved in multiple DNA transactions including DNA replication, transcription, chromosome condensation andExpand
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Targeting the p38 MAPK pathway inhibits irinotecan resistance in colon adenocarcinoma.
Despite recent advances in the treatment of colon cancer, tumor resistance is a frequent cause of chemotherapy failure. To better elucidate the molecular mechanisms involved in resistance toExpand
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Topoisomerase I inhibitors: selectivity and cellular resistance.
Topoisomerase I (top1) inhibitors (camptothecins and other structurally diverse compounds) are effective and promising anticancer agents. Determinants of selectivity toward cancer cells andExpand
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