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TNP 351
Known as:
TNP-351
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Methotrexate
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Novel pyrrolo[2,3-d]pyrimidine antifolate TNP-351: cytotoxic effect on methotrexate-resistant CCRF-CEM cells and inhibition of transformylases of de novo purine biosynthesis
F. Itoh
,
O. Russello
,
Hiroshi Akimoto
,
G. P. Beardsley
Cancer Chemotherapy and Pharmacology
2004
Corpus ID: 23870657
N-{4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl}-l-glutamic acid (TNP-351), characterized by a pyrrolo[2,3-d…
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Highly Cited
2003
Highly Cited
2003
A new and efficient synthesis of pyrrolo[2,3-d]pyrimidine anticancer agents: Alimta (LY231514, MTA), homo-Alimta, TNP-351, and some aryl 5-substituted pyrrolo[2,3-d]pyrimidines.
E. Taylor
,
B. Liu
The Journal of organic chemistry
2003
Corpus ID: 33926614
Alimta, as well as homo-Alimta, a nonbridged analogue of Alimta, and TNP-351 have been prepared by a new method that involves…
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2000
2000
Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. III. Synthesis and biological properties of N(omega)-masked ornithine analogs.
F. Itoh
,
Y. Yoshioka
,
K. Yukishige
,
S. Yoshida
,
K. Ootsu
,
H. Akimoto
Chemical & pharmaceutical bulletin
2000
Corpus ID: 24883994
The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-g lutamic acid (1b, TNP-351…
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1997
1997
Growth inhibitory effects of antifolates against an adriamycin-resistant human small cell lung cancer cell line.
K. Matsuo
,
K. Kiura
,
+6 authors
M. Harada
Acta medica Okayama
1997
Corpus ID: 20100382
We have established an Adriamycin (ADM)-resistant small cell lung cancer (SCLC) cell line, SBC-3/ADM 100, which shows…
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1996
1996
Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. II. Synthesis and antitumor activity of N5-substituted glutamine analogs.
F. Itoh
,
Y. Yoshioka
,
+4 authors
H. Akimoto
Chemical & pharmaceutical bulletin
1996
Corpus ID: 39959693
The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2, 3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid (1b, TNP-351…
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1996
1996
A Ring-Transformation/Ring-Annulation Strategy for the Synthesis of the DHFR Inhibitor, TNP-351: A Correction.
E. Taylor
,
Z. Mao
The Journal of organic chemistry
1996
Corpus ID: 37213845
1995
1995
Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. I: Synthesis and biological properties of pyrrolo[2,3-d]pyrimidine antifolates containing tetrazole congener of glutamic acid.
F. Itoh
,
K. Yukishige
,
M. Wajima
,
K. Ootsu
,
H. Akimoto
Chemical & pharmaceutical bulletin
1995
Corpus ID: 33466627
Either the alpha- or gamma-carboxyl group of the glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5- yl…
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1995
1995
[The clinical phase I study of TNP-351. The TNP-351 Research Committee].
T. Taguchi
,
H. Niitani
,
+7 authors
T. Sasaki
Gan to kagaku ryoho. Cancer & chemotherapy
1995
Corpus ID: 42412894
The clinical phase I study of TNP-351, an antifolate drug having a novel structure, was performed through a multicenter…
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1994
1994
Pharmacodynamics and factorial analysis of an anticancer agent, TNP-351.
Tamotsu Hishikawa
1994
Corpus ID: 75765067
1994
1994
Pharmacodynamics and factorial analysis of an anticancer agent, TNP-351.
菱川 保
,
白石 明
,
田口 鐵男
1994
Corpus ID: 90475006
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