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TNK2 wt Allele

Known as: Tyrosine Kinase, Non-Receptor, 2 wt Allele, ACK1, ACK1 Gene 
Human TNK1 wild-type allele is located within 3q29 and is approximately 46 kb in length. This allele, which encodes activated CDC42 kinase 1 protein… 
National Institutes of Health

Related topics

Related topics

9 relations
3q29Cell Differentiation processCell ProliferationHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Specificity and mechanism-of-action of the JAK2 tyrosine kinase inhibitors ruxolitinib and SAR302503 (TG101348)
Specificity and mechanism-of-action of the JAK2 tyrosine kinase inhibitors ruxolitinib and SAR302503 (TG101348) 
2014
2014
ACK1 Tyrosine Kinase Interacts with Histone Demethylase KDM3A to Regulate the Mammary Tumor Oncogene HOXA1*
Background: The molecular mechanism by which tyrosine kinases promote estrogen-independent ER-responsive gene expression is… 
Highly Cited
2011
Highly Cited
2011
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.
Highly Cited
2010
Highly Cited
2010
Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation
The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target… 
Highly Cited
2010
Highly Cited
2010
Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases
Activation of androgen receptor (AR) may have a role in the development of castration-resistant prostate cancer. Two… 
Highly Cited
2010
Highly Cited
2010
Effect of Ack1 tyrosine kinase inhibitor on ligand‐independent androgen receptor activity
Androgen receptor (AR) plays a critical role in the progression of both androgen‐dependent and androgen‐independent prostate… 
Highly Cited
2007
Highly Cited
2007
Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation
Activation of the androgen receptor (AR) may play a role in androgen-independent progression of prostate cancer. Multiple… 
Highly Cited
2007
Highly Cited
2007
Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation.
Cdc42-associated tyrosine kinase 1 (ACK1) is a specific down-stream effector of Cdc42, a Rho family small G-protein. Previous… 
Highly Cited
2005
Highly Cited
2005
SNX9 as an adaptor for linking synaptojanin‐1 to the Cdc42 effector ACK1
Highly Cited
2003
Highly Cited
2003
Biochemical Properties of the Cdc42-associated Tyrosine Kinase ACK1
ACK1 (activated Cdc42-associated kinase 1) is a nonreceptor tyrosine kinase and the only tyrosine kinase known to interact with… 
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