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TNFSF15 protein, human

Known as: TNFSF15, VEGI protein, human, TNF Superfamily Ligand TL1A 
Tumor necrosis factor ligand superfamily member 15 (251 aa, ~28 kDa) is encoded by the human TNFSF15 gene. This protein plays a role in both the… 
National Institutes of Health

Related topics

Related topics

14 relations
Angiogenesis InhibitionApoptosis Regulatory ProteinsCell DeathCytokine Gene

Broader (1)

Tumor Necrosis Factor Ligand Superfamily Member 15

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
Dietary encapsulated essential oils and organic acids mixture improves gut health in broiler chickens challenged with necrotic enteritis
The poultry industry is in need of effective antibiotic alternatives to control outbreaks of necrotic enteritis (NE) due to… 
Highly Cited
2018
Highly Cited
2018
Inflammation independent TL1A-mediated Intestinal Fibrosis is Dependent on the Gut Microbiome
Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease (IBD), modulating the location… 
Highly Cited
2012
Highly Cited
2012
TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNFα, from CD3+CD161+ T cells to exacerbate gut inflammation
Tumor necrosis factor (TNF)-like cytokine 1A (TL1A)/TNF superfamily member 15 (TNFSF15) is a proinflammatory cytokine and TNF… 
Highly Cited
2011
Highly Cited
2011
Constitutive TL1A (TNFSF15) Expression on Lymphoid or Myeloid Cells Leads to Mild Intestinal Inflammation and Fibrosis
TL1A is a member of the TNF superfamily and its expression is increased in the mucosa of inflammatory bowel disease patients… 
Highly Cited
2010
Highly Cited
2010
The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation
The tumor necrosis factor (TNF)-family cytokine TL1A (TNFSF15) costimulates T cells through its receptor DR3 (TNFRSF25) and is… 
Highly Cited
2009
Highly Cited
2009
IBD-Associated TL1A Gene (TNFSF15) Haplotypes Determine Increased Expression of TL1A Protein
Background The recently identified member of the TNF superfamily TL1A (TNFSF15) increases IFN-γ production by T cells in… 
Highly Cited
2008
Highly Cited
2008
TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.
BACKGROUND & AIMS TL1A is a tumor necrosis factor-like molecule that mediates a strong costimulation of T-helper (T(H)) 1 cells… 
Highly Cited
2007
Highly Cited
2007
TNFSF15 is an ethnic‐specific IBD gene
Background: Inflammatory bowel disease (IBD) is a clinically and, likely, genetically heterogeneous group of disorders. A recent… 
Highly Cited
2006
Highly Cited
2006
Neonatal and Adult CD4+CD3− Cells Share Similar Gene Expression Profile, and Neonatal Cells Up-Regulate OX40 Ligand in Response to TL1A (TNFSF15)1
We report here the quantitative expression of a set of immunity-related genes, including TNF family members, chemokine receptors… 
Highly Cited
2003
Highly Cited
2003
Structure and Inhibitory Effects on Angiogenesis and Tumor Development of a New Vascular Endothelial Growth Inhibitor*
Blocking angiogenesis is an attractive strategy to inhibit tumor growth, invasion, and metastasis. We describe here the structure… 
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