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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
TLDR
A highly significant association is found between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the receptor for the proinflammatory cytokine interleukin-23, which prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease.
6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.
TLDR
Serial metabolite monitoring identifies a novel phenotype of IBD patients resistant to 6-MP/AZA therapy biochemically characterized by suboptimal 6-TGN and preferential 6-MMPR production upon dose escalation.
Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease.
TLDR
I2 and anti-Escherichia coli outer membrane porin C are associated with Crohn's disease phenotypes, and patients with the highest level of serum reactivity toward an increasing number of microbiota have the greatest frequency of strictures, internal perforations, and small bowel surgery.
Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease.
TLDR
Serum responses to CBir1 independently identify a unique subset of patients with complicated CD patients, and this bacterial antigen was identified in a murine model and has a similar pattern of aberrant reactivity in a subset of CD patients.
Inflammatory Bowel Disease Characteristics Among African Americans, Hispanics, and Non-Hispanic Whites: Characterization of a Large North American Cohort
TLDR
There are racial differences in IBD family history, disease location and behavior, surgical history, and EIMs that may reflect underlying genetic variations and have important implications for diagnosis and management of disease.
Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens.
TLDR
There seem to be patient subsets with differing responses to selected microbial and autoantigens in Crohn's disease, rather than global loss of tolerance.
Prevalence of CARD15/NOD2 Mutations in Caucasian Healthy People
TLDR
Data confirm that CARD15/NOD2 acts in interaction with other unknown risk cofactors in Caucasians, and provide strong evidence that the penetrances of the most at-risk genotypes are low.
A novel NOD2/CARD15 haplotype conferring risk for Crohn disease in Ashkenazi Jews.
TLDR
In Ashkenazi Jews, unrecognized population-specific predisposing factor(s) exist on the 268S-JW1 haplotype at the IBD1 locus, suggesting the existence of a Jewish-specific additional disease-predisposing factor on this haplotype.
Risk Factors for Ulcerative Colitis in a Chinese Population: An Age-matched and Sex-matched Case-control Study
TLDR
Smoking was a protective factor for UC and exsmoking was associated with an increase risk of UC in a Chinese population, and family history of IBD was shown to be a risk for UC, whereas appendectomy wasassociated with a low risk forUC.
Serum Immune Responses Predict Rapid Disease Progression among Children with Crohn's Disease: Immune Responses Predict Disease Progression
TLDR
This is the first study to prospectively demonstrate that the time to develop a disease complication in children is significantly faster in the presence of immune reactivity, thereby predicting disease progression to more aggressive disease phenotypes among pediatric CD patients.
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