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TNFRSF12A protein, human

Known as: TweakR, Tumor Necrosis Factor Receptor Superfamily Member 12A, fibroblast growth factor inducible-14 protein, human 
Tumor necrosis factor receptor superfamily member 12A (129 aa, ~14 kDa) is encoded by the human TNFRSF12A gene. This protein is involved in both… 
National Institutes of Health

Related topics

Related topics

17 relations
Angiogenesis PromoterApoptosisApoptosis Regulatory ProteinsCytokine Receptor Gene

Broader (1)

TNFRSF12A protein

Papers overview

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2016
2016
Abstract 1210: Preclinical pharmacology and repeated dose toxicity of the novel agonistic TWEAK receptor binding antibody BAY-356
TWEAK receptor (TWEAKR, FN14) is a member of the tumor necrosis factor receptor superfamiliy and is highly expressed in a variety… 
2015
2015
TWEAK / Fn 14 interaction regulates RANTES production , BMP-2-induced differentiation , and RANKL expression in mouse osteoblastic MC 3 T 3E 1 cells
Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), a member of the TNF family, is a multifunctional cytokine… 
2013
2013
Cancer Therapy : Preclinical RG 7212 Anti-TWEAK mAb Inhibits Tumor Growth through Inhibition of Tumor Cell Proliferation and Survival Signaling and by Enhancing the Host Antitumor Immune Response
Purpose:Toexplore the role of TWEAK in tumor growthandantitumor immune response and the activity and mechanism of RG7212, an… 
Review
2012
Review
2012
The TWEAK-Fn14 System: Breaking the Silence of Cytokine-Induced Skeletal Muscle Wasting
The occurrence of skeletal muscle atrophy, a devastating complication of a large number of disease states and inactivity/disuse… 
2012
2012
[Effect of dexamethasone on expressions of TWEAK and Fn14 in the lung of asthmatic mice].
AIM To investigate the effect of dexamethasone (Dex) on the expressions of TNF-like weak inducer of apoptosis (TWEAK) and… 
2011
2011
TWEAK and TNF regulation of sclerostin: a novel pathway for the regulation of bone remodelling.
TNF-ligand and TNF-receptor family members have established essential roles in the regulation of bone remodelling. We showed… 
2011
2011
Abstract C18: A phase I study of enavatuzumab (PDL192, ABT-361), a first-in-class human monoclonal antibody targeting TWEAK (tumor necrosis factor-like inducer of apoptosis) receptor, in patients…
Background: TWEAK receptor (TweakR, TNFRSF12A, CD266) is a member of the TNF receptor superfamily and is expressed on a range of… 
2010
2010
[The expression of TWEAKR/Fn14 in Rheumatoid arthritis fibroblast-like synoviocytes].
AIM To investigate the mechanism of TWEAK on Rheumatoid arthritis fibroblast-like synoviocytes (RA FLS) activation and articular… 
2010
2010
Abstract B17: PDL192, a humanized antibody to TweakR exhibits potent antitumor activity in pancreatic cancer models
Approximately 42,000 new cases of pancreatic cancer were diagnosed in the United States in 2009, and the 5-year survival rate for… 
2008
2008
DNA Micro-Array Gene Expression Profiling of Angiogenesis in Collagen Gel Culture
We examined angiogenesis-related gene expression profiles using collagen gel culture and a DNA chip. After isolation of total RNA… 
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