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TMPRSS6 gene

Known as: MATRIPTASE 2, FLJ30744, TMPRSS6 
National Institutes of Health

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TMPRSS2 genematriptase 2

Papers overview

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2019
2019
The Association of TMPRSS6 Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, Indonesia
Multiple common variants in transmembrane protease serine 6 (TMPRSS6) were associated with the plasma iron concentration in… 
2017
2017
Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice
Tmprss6-mutated mask mice display iron deficiency anemia and high expression of hepcidin. The aim of the study was to determine… 
2016
2016
Effect of Erythropoietin, Iron Deficiency and Iron Overload on Liver Matriptase-2 (TMPRSS6) Protein Content in Mice and Rats
Matriptase-2 (TMPRSS6) is an important negative regulator of hepcidin expression; however, the effects of iron overload or… 
2015
2015
The controversial role of variants in HAMP , BMP 2 , FTL and SLC 40 A 1 genes
2013
2013
Treating iron overload.
Both hemochromatosis and β-thalassemia are caused by a deficiency of hepcidin, which represses expression of ferroportin at the… 
2012
2012
Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6.
2012
2012
Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region
Abstract The type II transmembrane serine protease matriptase-2 (TMPRSS6) down-regulates the expression of hepcidin, the main… 
2011
2011
Essential Role of Endocytosis of the Type II Transmembrane Serine Protease TMPRSS6 in Regulating Its Functionality*
The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative… 
2010
2010
EPO‐mediated reduction in Hamp expression in vivo corrects iron deficiency anaemia in TMPRSS6 deficiency
Hepcidin, a 25 amino acid liver-derived peptide, has been recognized as a regulator of iron homeostasis. Hepcidin levels are… 
2005
2005
Cloning and characterization of TMPRSS6, a novel type 2 transmembrane serine protease.
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