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TMPRSS2 gene

Known as: TRANSMEMBRANE PROTEASE, SERINE 2, PRSS10, ETV1/TMPRSS2 Fusion Gene 
A fusion gene that results from a chromosomal translocation t(7;21)(p21;q22) which fuses the 5' end of the TMPRSS2 gene with exon 4 of the ETV1 gene… 
National Institutes of Health

Related topics

Related topics

27 relations
Acinar Prostate Adenocarcinoma, Pseudohyperplastic VariantAcinar Prostate Adenocarcinoma, Sarcomatoid VariantAcinar Prostate Adenocarcinoma, Signet Ring VariantAcinar Prostate Mucinous Adenocarcinoma

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TMPRSS2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Prostate cancer: Mastering transcription: TMPRSS2–ERG and the cis-regulatory landscape
Genetics provide insight into the molecular processes driving ERG overexpression in prostate cancer. Moreover the effects of… 
2017
2017
Preurejanje genov TMPRSS2 in ERG ter njuna prognostična vloga pri slovenskih bolnikih s karcinomom prostate
Namen: Rak na prostati (CaP) je najpogostejsa rakasta bolezen pri moskih in eden glavnih razlogov zbolevnosti in umrljivosti. V… 
2015
2015
[Relationship between TMPRSS2: ERG and the pathological grade of prostate cancer].
OBJECTIVE To study the relationship between TMPRSS2: ERG gene fusion and the pathological grade of prostate cancer (PCa… 
2014
2014
Prostate cancer: BETting on epigenetic therapy
The bromodomain and extraterminal (BET) family of chromatin readers are important for androgen receptor-mediated transcription… 
2012
2012
Role of dutasteride in pre‐clinical ETS fusion‐positive prostate cancer models
Androgens play a crucial role in prostate cancer, hence the androgenic pathway has become an important target of therapeutic… 
Review
2012
Review
2012
t(8;21)(q24;q22) in prostate cancer
Review on t(8;21)(q24;q22) in prostate cancer, with data on clinics, and the genes involved. 
2011
2011
[Detection and significance of fusion gene between TMPRSS2 and ETS transcription factor genes in fresh prostatic cancer tissues in Chinese patients].
近年学者发现,大多数前列腺癌中跨膜丝氨酸蛋白酶2(TMPRSS2)基因与ETS转录因子家族的ERG、ETV1或ETV4之间可以发生融合,形成融合基因TMPRSS2-ERG、-ETV1和-ETV4(此型极少见),且它们可能还是重要预后指标[1-3… 
2010
2010
Prostate cancer: A new tARget
recurrent prostate cancer (CRPC) is generally believed to involve the androgen receptor (AR) in most patients. Current treatments… 
2008
2008
Abstract A91: Obesity and the TMPRSS2:ERG translocation in prostate cancer
A91 Background The recently identified TMPRSS2:ERG translocation is an early and common somatic event in prostate cancer… 
2007
2007
Absence of fusion of TMPRSS2 and ETS transcription factor genes in gastric and colorectal carcinomas
Cancers only become manifest following accumulation of somatic mutations. One of the most common types of somatic mutation is… 
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