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TMPRSS2 gene

Known as: TRANSMEMBRANE PROTEASE, SERINE 2, PRSS10, ETV1/TMPRSS2 Fusion Gene 
A fusion gene that results from a chromosomal translocation t(7;21)(p21;q22) which fuses the 5' end of the TMPRSS2 gene with exon 4 of the ETV1 gene… 
National Institutes of Health

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Related topics

27 relations
Acinar Prostate Adenocarcinoma, Pseudohyperplastic VariantAcinar Prostate Adenocarcinoma, Sarcomatoid VariantAcinar Prostate Adenocarcinoma, Signet Ring VariantAcinar Prostate Mucinous Adenocarcinoma

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TMPRSS2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections
Highly Cited
2016
Highly Cited
2016
Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay
ABSTRACT Middle East respiratory syndrome (MERS) is an emerging infectious disease associated with a relatively high mortality… 
Highly Cited
2013
Highly Cited
2013
The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies
ABSTRACT The novel human coronavirus EMC (hCoV-EMC), which recently emerged in Saudi Arabia, is highly pathogenic and could pose… 
Highly Cited
2012
Highly Cited
2012
The TMPRSS2:ERG Rearrangement, ERG Expression, and Prostate Cancer Outcomes: A Cohort Study and Meta-analysis
Background: Whether the genomic rearrangement transmembrane protease, serine 2 (TMPRSS2):v-ets erythroblastosis virus E26… 
Highly Cited
2009
Highly Cited
2009
Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin
ABSTRACT Proteolytic activation of the hemagglutinin (HA) protein is indispensable for influenza virus infectivity, and the… 
Highly Cited
2007
Highly Cited
2007
Diversity of TMPRSS2-ERG fusion transcripts in the human prostate
TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current… 
Highly Cited
2007
Highly Cited
2007
Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancer
The prostate-specific gene, TMPRSS2 is fused with the gene for the transcription factor ERG in a large proportion of human… 
Highly Cited
2006
Highly Cited
2006
TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions.
TMPRSS2-ETS gene fusions have been found recurrently in prostate carcinomas, but not in the presumed precursor lesion, high-grade… 
Highly Cited
1999
Highly Cited
1999
Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.
Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate… 
Highly Cited
1997
Highly Cited
1997
Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.
To contribute to the development of the transcription map of human chromosome 21 (HC21), we have used exon trapping from pools of… 
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