Absence of fusion of TMPRSS2 and ETS transcription factor genes in gastric and colorectal carcinomas

@article{Yoo2007AbsenceOF,
  title={Absence of fusion of TMPRSS2 and ETS transcription factor genes in gastric and colorectal carcinomas},
  author={N. Yoo and J. W. Lee and S. Lee},
  journal={APMIS},
  year={2007},
  volume={115}
}
Cancers only become manifest following accumulation of somatic mutations. One of the most common types of somatic mutation is chromosomal translocations that result in a chimeric transcript or apposition of one gene to regulatory regions of another gene. This mutation type is common in leukaemias, lymphomas and mesenchymal tumors. Although recurrent chromosomal translocations are rare in epithelial neoplasia, several examples have been reported among epithelial neoplasia, including thyroid… Expand

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