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matriptase 2

Known as: matriptase-2, matriptase-2, human 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Membrane ProteinsSerine Endopeptidases
TMPRSS6 gene

Papers overview

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2016
2016
En Route to New Therapeutic Options for Iron Overload Diseases: Matriptase‐2 as a Target for Kunitz‐Type Inhibitors
The cell‐surface serine protease matriptase‐2 is a critical stimulator of iron absorption by negatively regulating hepcidin, the… 
2015
2015
Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.
Increased expression of metalloprotease meprin β is associated with fibrotic syndromes and Alzheimer's disease (AD). Hence… 
2012
2012
Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region
Abstract The type II transmembrane serine protease matriptase-2 (TMPRSS6) down-regulates the expression of hepcidin, the main… 
Highly Cited
2010
Highly Cited
2010
Identification of the first low-molecular-weight inhibitors of matriptase-2.
As recently discovered, matriptase-2, a type II transmembrane serine protease, plays a crucial role in body iron homeostasis by… 
Highly Cited
2008
Highly Cited
2008
Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis.
Proteolytic events at the cell surface are essential in the regulation of signal transduction pathways. During the past years… 
Highly Cited
2008
Highly Cited
2008
A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron
Previous studies have described a familial syndrome characterized by iron malabsorption, hypoferremia, and microcytic anemia that… 
Review
2008
Review
2008
The type II transmembrane serine protease matriptase-2--identification, structural features, enzymology, expression pattern and potential roles.
Matriptase-2 (also known as TMPRSS6) is a recently identified member of the type II transmembrane serine protease (TTSP) family… 
2008
2008
Genetic upregulation of matriptase‐2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation
The cellular function and the role of matriptase‐2 in cancer progression are poorly understood. This study assesses the… 
2007
2007
Matriptase-2 Inhibits Breast Tumor Growth and Invasion and Correlates with Favorable Prognosis for Breast Cancer Patients
Purpose: The type II transmembrane serine proteases are cell surface proteolytic enzymes that mediate a diverse range of cellular… 
Highly Cited
2003
Highly Cited
2003
Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues.
We report the identification and characterization of mouse matriptase-2 (m-matriptase-2), an 811-amino-acid protein composed of… 
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