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TMPRSS2 protein, human

Known as: epitheliasin protein, human, transmembrane protease, serine 2 protein, human, EC 3.4.21.- 
Transmembrane protease serine 2 (492 aa, ~54 kDa) is encoded by the human TMPRSS2 gene. This protein plays a role in proteolysis.
National Institutes of Health

Related topics

Related topics

9 relations
Androgen Receptor Regulation PathwayEnzyme GeneHydrolysisPeptidase Gene

Broader (1)

Serine Endopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD
Review
2017
Review
2017
TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections
Highly Cited
2016
Highly Cited
2016
Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay
ABSTRACT Middle East respiratory syndrome (MERS) is an emerging infectious disease associated with a relatively high mortality… 
Highly Cited
2013
Highly Cited
2013
The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies
ABSTRACT The novel human coronavirus EMC (hCoV-EMC), which recently emerged in Saudi Arabia, is highly pathogenic and could pose… 
Highly Cited
2010
Highly Cited
2010
Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors
ABSTRACT Proteolytic cleavage of the influenza virus surface glycoprotein hemagglutinin (HA) by host cell proteases is crucial… 
Highly Cited
2010
Highly Cited
2010
TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells.
TMPRSS2, a type II transmembrane serine protease, is highly expressed by the epithelium of the human prostate gland. To explore… 
Highly Cited
2008
Highly Cited
2008
Efficient Multiplication of Human Metapneumovirus in Vero Cells Expressing the Transmembrane Serine Protease TMPRSS2
ABSTRACT Human metapneumovirus (HMPV) is a major causative agent of severe bronchiolitis and pneumonia. Its fusion (F) protein… 
Highly Cited
2005
Highly Cited
2005
The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.
TMPRSS2 is a type II transmembrane-bound serine protease that has gained interest owing to its highly localized expression in the… 
Highly Cited
1999
Highly Cited
1999
Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.
Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate… 
Highly Cited
1997
Highly Cited
1997
Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.
To contribute to the development of the transcription map of human chromosome 21 (HC21), we have used exon trapping from pools of… 
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