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TMEM171 gene

Known as: PRP2, TMEM171, transmembrane protein 171 
National Institutes of Health

Papers overview

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2017
2017
Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency
Significance The spliceosome, which catalyzes pre-mRNA splicing via a two-step process, must balance the need for high-fidelity… 
2017
2017
Yeast Prp2 liberates the 5′ splice site and the branch site adenosine for catalysis of pre-mRNA splicing
The RNA helicase Prp2 facilitates the remodeling of the spliceosomal Bact complex to the catalytically activated B* complex just… 
Highly Cited
2012
Highly Cited
2012
The Interaction of Prp2 with a Defined Region of the Intron Is Required for the First Splicing Reaction
ABSTRACT In Saccharomyces cerevisiae, the 3′ splice site is not required for the first catalytic reaction of splicing. We have… 
2010
2010
Splicing Factor Cwc22 Is Required for the Function of Prp2 and for the Spliceosome To Escape from a Futile Pathway
ABSTRACT Cwc22 was previously identified to associate with the pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19… 
Highly Cited
2009
Highly Cited
2009
Cwc25 Is a Novel Splicing Factor Required after Prp2 and Yju2 To Facilitate the First Catalytic Reaction
ABSTRACT Cwc25 has previously been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19… 
2004
2004
Definition of a spliceosome interaction domain in yeast Prp2 ATPase.
The Saccharomyces cerevisiae splicing factor Prp2 is an RNA-dependent ATPase required before the first transesterification… 
1998
1998
A Link between Secretion and Pre-mRNA Processing Defects in Saccharomyces cerevisiae and the Identification of a Novel Splicing Gene, RSE1
ABSTRACT Secretory proteins in eukaryotic cells are transported to the cell surface via the endoplasmic reticulum (ER) and the… 
Highly Cited
1996
Highly Cited
1996
Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing
In addition to small nuclear RNAs and spliceosomal proteins, ATP hydrolysis is needed for nuclear pre-mRNA splicing. A number of… 
Highly Cited
1995
Highly Cited
1995
The final stages of spliceosome maturation require Spp2p that can interact with the DEAH box protein Prp2p and promote step 1 of splicing.
Pre-mRNA processing occurs by assembly of splicing factors on the substrate to form the spliceosome followed by two consecutive… 
Highly Cited
1992
Highly Cited
1992
The purified yeast pre‐mRNA splicing factor PRP2 is an RNA‐dependent NTPase.
Unlike autocatalyzed self‐splicing reactions, nuclear pre‐mRNA splicing requires transacting macromolecules and ATP. A protein… 
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