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TMC-95A

Known as: TMC 95A 
National Institutes of Health

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1 relation

Broader (1)

Cyclic Peptides

Papers overview

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2015
2015
Proteasome Inhibition in Lymphoproliferative Disorder
Proteasomes are multi-subunit protein complexes, which present numerous targets for therapeutic interference. The most commonly… 
2014
2014
Noncovalent fluorescent probes of human immuno- and constitutive proteasomes.
We report here the synthesis and biological evaluation of fluorescent probes functioning as inhibitors that noncovalently block… 
2012
2012
Noncovalent inhibition of 20S proteasome by pegylated dimerized inhibitors.
2012
2012
Les 3-hydroxyoxindoles : de la synthèse du motif aux études vers les synthèses totales du TMC-95A et de l’azonazine
Le motif 3-hydroxyoxindole est present dans de nombreuses molecules biologiquement actives, qu’elles soient d’origine naturelle… 
2008
2008
Vers la synthèse de nouveaux analogues du TMC-95A : formation régiosélective d'oxindoles substitués
Les travaux decrits dans cette these concernent l’approche vers la synthese de nouveaux analogues du TMC-95A, molecule naturelle… 
2006
2006
Total synthesis of TMC-95A and pinnatoxin A and synthetic study of antillatoxin
2005
2005
Conception, synthèse et évaluation enzymatique d'analogues du TMC-95A, un inhibiteur du protéasome
Le proteasome est une protease multicatalytique complexe impliquee dans le developpement de pathologies majeures. Son inhibition… 
Highly Cited
2003
Highly Cited
2003
A concise formal total synthesis of TMC-95A/B proteasome inhibitors.
[reaction: see text] A formal total synthesis of proteasome inhibitors TMC-95A/B is described. The synthesis features a… 
2003
2003
Simplified Synthetic TMC‐95A/B Analogues Retain the Potency of Proteasome Inhibitory Activity
The proteasome regulates diverse intracellular processes, including cell‐cycle progression, antigen presentation, and… 
2002
2002
Synthesis of TMC-95A analogues. Structure-based prediction of cyclization propensities of linear precursors
Cyclization of a TMC-95A related tripeptide precursor with the preformed C6-indole/phenol junction was found to produce… 
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