• Publications
  • Influence
Structure of TPR Domain–Peptide Complexes Critical Elements in the Assembly of the Hsp70–Hsp90 Multichaperone Machine
TLDR
The adaptor protein Hop mediates the association of the molecular chaperones Hsp70 and Hsp90 with the help of the TPR domains, which participate in the ordered assembly of HSp70-Hsp90 multichaperone complexes. Expand
A gated channel into the proteasome core particle
TLDR
Crystallographic analysis showed that deletion of the tail of the α3-subunit opens a channel into the proteolytically active interior chamber of the CP, thus derepressing peptide hydrolysis. Expand
Mutational studies on HslU and its docking mode with HslV.
TLDR
ATP-binding site mutations confirm the essential role of the "sensor arginine" and the "arginine finger" in the ATPase action of HslU and demonstrate an important role for E321, and a better refined structure of the HslVU complex crystallized along with resorufin-labeled casein is reported. Expand
Iodoacetamide-induced artifact mimics ubiquitination in mass spectrometry
TLDR
NPG Nature Asia-Pacific, 2-37 Ichigayatamachi, Shinjuku-ku, Tokyo 162-0843, Tel: 81 (03) 3267 8751, Fax: 81-03- 3267 8746. Expand
Expansion of the genetic code enables design of a novel "gold" class of green fluorescent proteins.
TLDR
An expansion of efforts by incorporation of an amino substituted variant of tryptophan into the "cyan" GFP mutant, which turned it into a "gold" variant, which possesses a red shift in emission unprecedented for any avFP. Expand
Single-Molecule Optomechanical Cycle
TLDR
The polymer was found to contract against an external force acting along the polymer backbone, thus delivering mechanical work, demonstrating for the first time optomechanical energy conversion in a single-molecule device. Expand
Identification of Two Amino Acids of the Human Cholecystokinin-A Receptor That Interact with the N-terminal Moiety of Cholecystokinin*
TLDR
The modeling of the CCK-A receptor and the docking of the peptide agonists indicated that their N terminus was connected to the receptor through a strong bond network involving Trp-39 and Gln-40 thus confirming experimental data, an important step toward the complete delineation of the agonist binding site. Expand
Arginine 197 of the cholecystokinin‐A receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin
TLDR
Data support an interaction between Arg 197 of the CCK‐AR binding site and the sulfate of CCK, suggesting that Arg 197‐sulfate interaction regulates conformational changes of the CCP‐AR that are required for its physiological activation. Expand
Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases.
TLDR
The results confirm the usefulness of synthetic heterotrimeric collagenous peptides in the folded and unfolded state as mimics of the natural substrates collagen and gelatin, respectively, to gain a better a insight into the proteolytic mechanisms of matrix metalloproteinases. Expand
Practical aspects of the 2D 15N-{1H}-NOE experiment
TLDR
The results of this study show that commonly used parameters are only adequate for accurate measurement of motions with moderate amplitude, and that highly flexible parts require longer delay times and thus more experimental time than commonly used. Expand
...
1
2
3
4
5
...