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TITF1 protein, human

Known as: Homeobox protein NK-2 homolog A, Thyroid Transcription Factor, Homeobox protein Nkx-2.1 
Thyroid transcription factor 1 (371 aa, ~39 kDa) is encoded by the human NKX2-1 gene. This protein is involved in transcriptional regulation.
National Institutes of Health

Related topics

Related topics

11 relations
DNA-Binding ProteinsGenes, RegulatorHomeodomain ProteinsNK2 Homeobox 1 Measurement

Broader (1)

thyroid transcription factor 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
Highly Cited
2010
Highly Cited
2010
Transcription factor mutations and congenital hypothyroidism: systematic genetic screening of a population-based cohort of Japanese patients.
CONTEXT Gene mutations of transcription factors that are predominantly expressed in the thyroid gland cause congenital… 
Highly Cited
2008
Highly Cited
2008
Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer
Lung cancer is a leading cause of cancer death, where the amplification of oncogenes contributes to tumorigenesis. Genomic… 
Highly Cited
2004
Highly Cited
2004
Autosomal dominant transmission of congenital hypothyroidism, neonatal respiratory distress, and ataxia caused by a mutation of NKX2-1.
Highly Cited
2004
Highly Cited
2004
TTF-1 expression is specific for lung primary in typical and atypical carcinoids: TTF-1-positive carcinoids are predominantly in peripheral location.
Highly Cited
2004
Highly Cited
2004
Expression of TTF‐1 and cytokeratins in primary and secondary epithelial lung tumours: correlation with histological type and grade
Aims:  To assess cytokeratin (CK) and thyroid transcription factor (TTF)‐1 expression in primary epithelial lung tumours by… 
Highly Cited
2002
Highly Cited
2002
TTF-1 Expression in Pulmonary Adenocarcinomas
Tissue-specific gene expression is mediated largely by transcription factors, and a master regulatory gene is thus a potential… 
Highly Cited
2002
Highly Cited
2002
Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency.
The occurrence of neurological symptoms and developmental delay in patients affected by congenital hypothyroidism (CH) has been… 
Highly Cited
2001
Highly Cited
2001
FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo.
Transgenic mice in which fibroblast growth factor (FGF)-10 was expressed in the lungs of fetal and postnatal mice were generated… 
Highly Cited
1994
Highly Cited
1994
The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along…
We used the lung epithelial cell-specific surfactant protein B (SPB) gene promoter as a model with which to investigate… 
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