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THRB gene

Known as: Genes, TR beta, beta Genes, TR, THRB Genes 
This gene plays a role in receptor signaling and regulation of transcription. It is involved in inner ear development and color vision.
National Institutes of Health

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Biologic DevelopmentCell Differentiation processCell ProliferationHomeostasis
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THRB wt Allele

Papers overview

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Highly Cited
2001
Highly Cited
2001
Genetic Analysis Reveals Different Functions for the Products of the Thyroid Hormone Receptor α Locus
ABSTRACT Thyroid hormone receptors are encoded by the TRα(NR1A1) and TRβ (NR1A2) loci. These genes are transcribed into multiple… Expand
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Highly Cited
2000
Highly Cited
2000
Cloning and Characterization of Two Novel Thyroid Hormone Receptor β Isoforms
  • G. Williams
  • Molecular and Cellular Biology
  • 2000
    • Corpus ID: 40735143
ABSTRACT Thyroid hormone (T3) activates nuclear receptor transcription factors, encoded by the TRα (NR1A1) and TRβ (NR1A2) genes… Expand
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Highly Cited
1999
Highly Cited
1999
Proteasome-dependent degradation of the human estrogen receptor.
In eukaryotic cells, the ubiquitin-proteasome pathway is the major mechanism for the targeted degradation of proteins with short… Expand
Highly Cited
1998
Highly Cited
1998
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor.
BACKGROUND Thyroid hormones regulate many different physiological processes in different tissues in vertebrates. Most of the… Expand
Highly Cited
1997
Highly Cited
1997
The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans.
  • T. C. White
  • Antimicrobial agents and chemotherapy
  • 1997
    • Corpus ID: 2770989
Azole resistance in the pathogenic yeast Candida albicans is an emerging problem in the human immunodeficiency virus (HIV… Expand
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Highly Cited
1994
Highly Cited
1994
Alpha and beta thyroid hormone receptor (TR) gene expression during auditory neurogenesis: evidence for TR isoform-specific transcriptional regulation in vivo.
Clinicians have long recognized that congenital deficiency of iodine (a component of thyroid hormone) somehow damages the human… Expand
Highly Cited
1994
Highly Cited
1994
Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta gene.
Resistance to thyroid hormone (RTH), with elevated serum free thyroid hormones and nonsuppressed thyrotropin levels, is either… Expand
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Highly Cited
1993
Highly Cited
1993
Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.
The human thyroid hormone receptor beta (hTR beta) is capable of both transcriptional silencing and hormone-dependent activation… Expand
Highly Cited
1993
Highly Cited
1993
Attention deficit-hyperactivity disorder in people with generalized resistance to thyroid hormone.
BACKGROUND Attention deficit-hyperactivity disorder is a well-recognized psychiatric disorder of childhood. Its cause is unknown… Expand
Highly Cited
1990
Highly Cited
1990
Contrasting developmental and tissue‐specific expression of alpha and beta thyroid hormone receptor genes.
Thyroid hormones and their receptors (TRs) have critical functions in development. Here we show that a chicken TR beta cDNA clone… Expand
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