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THRB gene
Known as:
Genes, TR beta
, beta Genes, TR
, THRB Genes
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This gene plays a role in receptor signaling and regulation of transcription. It is involved in inner ear development and color vision.
National Institutes of Health
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Related topics
Related topics
15 relations
Biologic Development
Cell Differentiation process
Cell Proliferation
Homeostasis
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THRB wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats.
Cássio M Villicev
,
F. R. Freitas
,
+6 authors
C. H. Gouveia
Journal of Endocrinology
2007
Corpus ID: 18405436
It is well known that thyroid hormone affects body composition; however, the effect of the thyroid hormone receptor beta (TRbeta…
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Highly Cited
2000
Highly Cited
2000
Cloning and Characterization of Two Novel Thyroid Hormone Receptor β Isoforms
G. Williams
Molecular and Cellular Biology
2000
Corpus ID: 40735143
ABSTRACT Thyroid hormone (T3) activates nuclear receptor transcription factors, encoded by the TRα (NR1A1) and TRβ (NR1A2) genes…
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Highly Cited
1996
Highly Cited
1996
Cloning and characterization of a melanin biosynthetic THR1 reductase gene essential for appressorial penetration of Colletotrichum lagenarium.
Perpetua Ns
,
Yasuyuki Kubo
,
N. Yasuda
,
Yoshitaka Takano
,
Iwao Furusawa
Molecular Plant-Microbe Interactions
1996
Corpus ID: 25878524
Melanin biosynthesis of Colletotrichum lagenarium is essential for appressorial penetration of the host plant. A melanin…
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Highly Cited
1994
Highly Cited
1994
Alpha and beta thyroid hormone receptor (TR) gene expression during auditory neurogenesis: evidence for TR isoform-specific transcriptional regulation in vivo.
D. J. Bradley
,
H. Towle
,
W. Young
Proceedings of the National Academy of Sciences…
1994
Corpus ID: 11437541
Clinicians have long recognized that congenital deficiency of iodine (a component of thyroid hormone) somehow damages the human…
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Highly Cited
1994
Highly Cited
1994
Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta gene.
M. Adams
,
C. Matthews
,
T N Collingwood
,
Y. Tone
,
P. Beck-Peccoz
,
K. Chatterjee
Journal of Clinical Investigation
1994
Corpus ID: 323187
Resistance to thyroid hormone (RTH), with elevated serum free thyroid hormones and nonsuppressed thyrotropin levels, is either…
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Highly Cited
1993
Highly Cited
1993
Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.
A. Baniahmad
,
Ilho HAt
,
Danny REINBERGt
,
Sophia Y. Tsai
,
M. Tsai
,
B. W. O'malley
Proceedings of the National Academy of Sciences…
1993
Corpus ID: 20245917
The human thyroid hormone receptor beta (hTR beta) is capable of both transcriptional silencing and hormone-dependent activation…
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Highly Cited
1993
Highly Cited
1993
Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine-guanine-rich areas of the thyroid hormone receptor beta gene. Analysis of 15 families.
R. Weiss
,
M. Weinberg
,
S. Refetoff
Journal of Clinical Investigation
1993
Corpus ID: 11092944
Generalized resistance to thyroid hormone (GRTH) is a syndrome of variable reduction of tissue responsiveness to thyroid hormone…
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Highly Cited
1991
Highly Cited
1991
Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain.
Roberto Parnila
,
A. J. Mixson
,
J. Mcpherson
,
J. Mcclaskey
,
B. Weintraub
Journal of Clinical Investigation
1991
Corpus ID: 11184686
Genetic analysis in our laboratory of families with generalized thyroid hormone resistance (GTHR) has demonstrated tight linkage…
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Highly Cited
1990
Highly Cited
1990
Dominant negative transcriptional regulation by a mutant thyroid hormone receptor-beta in a family with generalized resistance to thyroid hormone.
A. Sakurai
,
T. Miyamoto
,
Samuel Refetoff
,
L. DeGroot
Molecular Endocrinology
1990
Corpus ID: 8669020
An abnormal human thyroid hormone beta-receptor (hTR beta-Mf), which has a glycine to arginine substitution in the hormone…
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Highly Cited
1990
Highly Cited
1990
A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds.
S. Usala
,
Gregory E. Tennyson
,
+6 authors
B D Weintraub
Journal of Clinical Investigation
1990
Corpus ID: 9905326
Generalized thyroid hormone resistance (GTHR) is a disorder of thyroid hormone action that we have previously shown to be tightly…
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