Oxytocin: The great facilitator of life
- Heon-Jin Lee, A. Macbeth, J. Pagani, W. Young
- BiologyProgress in neurobiology
- 1 June 2009
Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution.
- M. Li, X. Liu, P. Furth
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 April 1997
It is demonstrated that genetic events that occur during the first reversible stage of mammary gland involution are controlled by local factors and mammary-derived death signals are dominant over protective effects related to systemic hormone stimulation.
Vasopressin: Behavioral roles of an “original” neuropeptide
- H. Caldwell, Heon-Jin Lee, A. Macbeth, W. Young
- BiologyProgress in neurobiology
- 31 January 2008
Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing study
Vasopressin V1b receptor knockout reduces aggressive behavior in male mice
- S. Wersinger, E. Ginns, A. O'Carroll, S. Lolait, W. Young
- Biology, PsychologyMolecular Psychiatry
Fos-mapping within chemosensory responsive regions suggests that the behavioral deficits in V1bR knockout mice are not due to defects in detection and transmission of chemOSensory signals to the brain, and suggests that V 1bR antagonists could prove useful for treating aggressive behavior seen in dementias and traumatic brain injuries.
A conditional knockout mouse line of the oxytocin receptor.
- Heon-Jin Lee, H. Caldwell, A. Macbeth, Selen G Tolu, W. Young
- Biology, PsychologyEndocrinology
- 1 July 2008
The results confirm the importance of oxytocin in social recognition and demonstrate that spatial and temporal inactivation of the Oxtr will enable finer understanding of the physiological, behavioral, and developmental roles of the receptor.
Hypothalamic and other connections with dorsal CA2 area of the mouse hippocampus
Novel connections from the PVN and to the SUM suggest important regulatory roles for CA2 in mediating social and emotional input for memory processing, consistent with recent observations that the dorsal CA2 forms disynaptic connections with the entorhinal cortex to influence dynamic memory processing.
A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse.
- A. Mason, J. Hayflick, P. Seeburg
- 12 December 1986
The partially deleted gene for the common biosynthetic precursor of gonadotropin-releasing hormone and GnRH-associated peptide is transcriptionally active as revealed by in situ hybridization histochemistry of hpg hypothalamic tissue sections, but immunocytochemical analysis failed to show the presence of antigen corresponding to any part of the precursor protein.
Dopamine differentially regulates dynorphin, substance P, and enkephalin expression in striatal neurons: in situ hybridization histochemical analysis
- C. Gerfen, JF McGinty, W. Young
- BiologyJournal of Neuroscience
- 1 April 1991
The expression of dynorphin, enkephalin, and substance P is differentially regulated by the mesostriatal dopaminergic system and, further, suggests that the mechanisms by which this regulation occurs may be different for the 3 peptide families.
Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.
We used in situ hybridization histochemistry with synthetic oligodeoxyribonucleotide probes to identify cells that synthesize mRNAs encoding tyrosine hydroxylase in the mesencephalon and substance P,…