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Oxytocin: The great facilitator of life
Oxytocin (Oxt) is a nonapeptide hormone best known for its role in lactation and parturition. Since 1906 when its uterine-contracting properties were described until 50 years later when its sequenceExpand
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Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution.
  • M. Li, X. Liu, +5 authors P. Furth
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 April 1997
Programmed cell death (PCD) of mammary alveolar cells during involution commences within hours of the end of suckling. Locally, milk accumulates within alveolar lumens; systemically, levels ofExpand
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Vasopressin: Behavioral roles of an “original” neuropeptide
Vasopressin (Avp) is mainly synthesized in the magnocellular cells of the hypothalamic supraoptic (SON) and paraventricular nuclei (PVN) whose axons project to the posterior pituitary. Avp is thenExpand
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Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing study
In situ hybridization histochemistry using cDNA oligonucleotide probes for the neuropeptides dynorphin, enkephalin and substance P was used to map the distribution of peptidergic neurons in theExpand
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Vasopressin V1b receptor knockout reduces aggressive behavior in male mice
Increased aggression is commonly associated with many neurological and psychiatric disorders. Current treatments are largely empirical and are often accompanied by severe side effects, underscoringExpand
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A conditional knockout mouse line of the oxytocin receptor.
Oxytocin plays important roles in reproductive physiology and various behaviors, including maternal behavior and social memory. Its receptor (Oxtr) is present in peripheral tissues and brain, so aExpand
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A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse.
Hereditary hypogonadism in the hypogonadal (hpg) mouse is caused by a deletional mutation of at least 33.5 kilobases encompassing the distal half of the gene for the common biosynthetic precursor ofExpand
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Dopamine differentially regulates dynorphin, substance P, and enkephalin expression in striatal neurons: in situ hybridization histochemical analysis
Dopamine regulation of the levels of dynorphin, enkephalin, and substance P messenger RNAs in rat striatal neurons was analyzed with in situ hybridization histochemistry (ISHH). Relative levels ofExpand
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Hypothalamic and other connections with dorsal CA2 area of the mouse hippocampus
The CA2 area is an important, although relatively unexplored, component of the hippocampus. We used various tracers to provide a comprehensive analysis of CA2 connections in C57BL/6J mice. UsingExpand
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The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy
The vasopressin 1b receptor (Avpr1b) is one of two principal receptors mediating the behavioral effects of vasopressin (Avp) in the brain. Avpr1b has recently been shown to strongly influence socialExpand
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