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Attention deficit-hyperactivity disorder in people with generalized resistance to thyroid hormone.
TLDR
In the study sample, attention deficit-hyperactivity disorder is strongly associated with generalized resistance to thyroid hormone.
Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain.
TLDR
Direct sequencing of polymerase chain reaction-amplified exons of the c-erbA beta gene is used to rapidly identify novel point mutations from seven previously uncharacterized kindreds with GTHR, and distinct topographic clustering of the mutations provides an invaluable genetic tool for the molecular dissection of thyroid receptor function.
Peptide-based Antifungal Therapies against Emerging Infections.
TLDR
A review of recent advances in peptide therapy for opportunistic fungal infections to discuss the utility and potential of selected peptides as efficient antifungal drugs with acceptable toxicity profiles.
Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice.
TLDR
Gene therapy transfer of angiostatin and endostatin represents an alternative method of delivering angiogenic polypeptide inhibitors and provides a basis for the further development of nonviral delivery of antiangiogenic genes.
Alteration in the IL‐2 signal peptide affects secretion of proteins in vitro and in vivo
TLDR
This study investigated whether alterations in the basic and/or the hydrophobic domains of a commonly used signal peptide from interleukin‐2 (IL‐2) affected secretion of two proteins: placental alkaline phosphatase (AP) and endostatin.
Thyrotropin-secreting pituitary carcinoma.
TLDR
Of all the reported cases of TSH-secreting adenomas, this case had the highest alpha-subunit portending future metastases, and this case underscores the need for early diagnosis and aggressive treatment of these tumors.
Optimal transfection with the HK polymer depends on its degree of branching and the pH of endocytic vesicles.
TLDR
The linear HK polymer enhanced gene expression in primary cell lines more effectively than the branched polymers, and binding data support the relationship between DNA release from the optimal HK polymer and endosomal pH.
Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo
TLDR
Evidence is provided that Raf-1 siRNA may be an effective strategy for reducing tumor growth by screening several histidine–lysine polymers in complex with Raf- 1 siRNA to reduce tumor growth in vivo.
Modified branched peptides with a histidine-rich tail enhance in vitro gene transfection
TLDR
Two branched histidine-lysine (HK) peptides are modified by adding a Histidine-rich tail and together with modification of the transfection protocol, these improved HK peptides alone are the effective carriers of plasmids into a variety of cells.
Systemic delivery of HK Raf-1 siRNA polyplexes inhibits MDA-MB-435 xenografts
TLDR
It is found that branched HK polymers in complex with Raf-1 siRNA markedly decreased Raf- 1 mRNA and induced apoptosis in cell lines in vitro, and there was little evidence of toxicity in normal tissues with this therapy.
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