THK5351
National Institutes of Health
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BackgroundTHK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target…
Background: Imaging studies in Alzheimer’s disease (AD) have yet to answer the underlying questions concerning the relationship…
PurposeWe investigated the regional distribution of 18F-THK5351 uptake in gray (GM) and white matter (WM) in patients with…
PurposeOff-target binding in the reference region is a challenge for recent tau tracers 18F-AV-1451 and 18F-THK5351. The…
BackgroundThe aim of this study was to compare the binding properties of several tau positron emission tomography tracers—THK5117…
PurposeTau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer’s disease and…
The radiotracer, [18 F]-THK-5351, is a highly selective and high-binding affinity PET imaging agent for aggregates of hyper…
Abnormal aggregation of tau in the brain is a major contributing factor in various neurodegenerative diseases. The role of tau…
Imaging of neurofibrillary pathology in the brain helps in diagnosing dementia, tracking disease progression, and evaluating the…
Purpose18F-THK5351 is a novel radiotracer developed for in vivo imaging of tau pathology in the brain. For the quantitative…