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THK5351

National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

18F-THK5351

Broader (2)

AminopyridinesQuinolines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report
BackgroundTHK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target… Expand
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2018
2018
Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer’s Disease: A PET (THK5351, PiB) and Resting fMRI Study
Background: Imaging studies in Alzheimer’s disease (AD) have yet to answer the underlying questions concerning the relationship… Expand
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2018
2018
Differences in gray and white matter 18F-THK5351 uptake between behavioral-variant frontotemporal dementia and other dementias
PurposeWe investigated the regional distribution of 18F-THK5351 uptake in gray (GM) and white matter (WM) in patients with… Expand
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2018
2018
Quantitative evaluation of tau PET tracers 18F-THK5351 and 18F-AV-1451 in Alzheimer’s disease with standardized uptake value peak-alignment (SUVP) normalization
PurposeOff-target binding in the reference region is a challenge for recent tau tracers 18F-AV-1451 and 18F-THK5351. The… Expand
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2018
2018
Neuroimaging-pathological correlations of [18F]THK5351 PET in progressive supranuclear palsy
Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of… Expand
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2017
2017
Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains
BackgroundThe aim of this study was to compare the binding properties of several tau positron emission tomography tracers—THK5117… Expand
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2017
2017
Head to head comparison of [18F] AV-1451 and [18F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia
  • Y. Jang, C. Lyoo, +14 authors S. Seo
  • European Journal of Nuclear Medicine and…
  • 2017
    • Corpus ID: 9321194
PurposeTau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer’s disease and… Expand
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2017
2017
A report of the automated radiosynthesis of the tau positron emission tomography radiopharmaceutical, [18 F]-THK-5351.
The radiotracer, [18 F]-THK-5351, is a highly selective and high-binding affinity PET imaging agent for aggregates of hyper… Expand
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Highly Cited
2016
Highly Cited
2016
18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease
Imaging of neurofibrillary pathology in the brain helps in diagnosing dementia, tracking disease progression, and evaluating the… Expand
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2016
2016
Characterization of the radiolabeled metabolite of tau PET tracer 18F-THK5351
Purpose18F-THK5351 is a novel radiotracer developed for in vivo imaging of tau pathology in the brain. For the quantitative… Expand
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