TGFB1-Induced Anti-Apoptotic Factor 1
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Anti-apoptotic Bfl-1 and pro-apoptotic Bax, two members of the Bcl-2 family sharing a similar structural fold, are classically… Expand The proteasome inhibitor bortezomib has shown remarkable clinical success in the treatment of multiple myeloma. However, the… Expand p73, the structural and functional homologue of p53, exists as two major forms: the transactivation-proficient, proapoptotic… Expand Background Ventricular remodeling in type 2 diabetes predisposes to fatal coronary heart disease. The proapoptotic forkhead class… Expand Reactive oxygen species (ROS) are important mediators for several biologic responses, including apoptosis. The present study… Expand Glucocorticoids promote thymocyte apoptosis and modulate transcription of numerous genes. GILZ (glucocorticoid-induced leucine… Expand Survivin is an inhibitor of apoptosis protein (IAP) that is markedly overexpressed in most cancers. We identified two novel… Expand