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TGFB1-Induced Anti-Apoptotic Factor 1

Known as: 12 kDa TGF-Beta-1-Induced Antiapoptotic Factor, TGF-Beta-1-Induced Antiapoptotic Factor 1 
TGFB1-induced anti-apoptotic factor 1 (115 aa, ~12 kDa) is encoded by the human TIAF1 gene. This protein plays a role in the modulation of apoptosis.
National Institutes of Health

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6 relations
ApoptosisApoptosis InhibitorGenes, RegulatorNegative Regulation of Apoptosis

Papers overview

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2012
2012
µ-Calpain Conversion of Antiapoptotic Bfl-1 (BCL2A1) into a Prodeath Factor Reveals Two Distinct alpha-Helices Inducing Mitochondria-Mediated Apoptosis
Anti-apoptotic Bfl-1 and pro-apoptotic Bax, two members of the Bcl-2 family sharing a similar structural fold, are classically… 
Highly Cited
2012
Highly Cited
2012
The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4
The proteasome inhibitor bortezomib has shown remarkable clinical success in the treatment of multiple myeloma. However, the… 
Highly Cited
2010
Highly Cited
2010
The antiapoptotic DeltaNp73 is degraded in a c-Jun–dependent manner upon genotoxic stress through the antizyme-mediated pathway
p73, the structural and functional homologue of p53, exists as two major forms: the transactivation-proficient, proapoptotic… 
Highly Cited
2008
Highly Cited
2008
Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat
Background Ventricular remodeling in type 2 diabetes predisposes to fatal coronary heart disease. The proapoptotic forkhead class… 
Highly Cited
2004
Highly Cited
2004
Oxidative stress mediates apoptotic changes induced by hyperglycemia in human tubular kidney cells.
Reactive oxygen species (ROS) are important mediators for several biologic responses, including apoptosis. The present study… 
Highly Cited
2004
Highly Cited
2004
Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice.
Glucocorticoids promote thymocyte apoptosis and modulate transcription of numerous genes. GILZ (glucocorticoid-induced leucine… 
Highly Cited
2002
Highly Cited
2002
Differential subcellular localization of functionally divergent survivin splice variants
Survivin is an inhibitor of apoptosis protein (IAP) that is markedly overexpressed in most cancers. We identified two novel… 
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