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TFRC gene

Known as: TFR, TRANSFERRIN RECEPTOR 1, TFRC 
This gene plays a regulatory role in receptor-mediated endocytosis and iron metabolism.
National Institutes of Health

Related topics

Related topics

11 relations
ErythropoiesisHomo sapiensIonophore activityLigand Binding

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TFRC wt Allele

Papers overview

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Highly Cited
2005
Highly Cited
2005
Delivery of β-Galactosidase to Mouse Brain via the Blood-Brain Barrier Transferrin Receptor
Enzyme replacement therapy of lysosomal storage disorders is complicated by the lack of enzyme transport across the blood-brain… 
Highly Cited
2002
Highly Cited
2002
Association of human transferrin receptor with GABARAP
2001
2001
Tyrphostin-8 Enhances Transferrin Receptor-Mediated Transcytosis in Caco-2 Cells and Increases Hypoglycemic Effect of Orally Administered Insulin-Transferrin Conjugate in Diabetic Rats
AbstractPurpose. To investigate the effect of tyrphostin 8 (T-8), a GTPase inhibitor, on transferrin receptor (TfR)-mediated… 
2000
2000
Site-specific expression of transferrin receptor by human colon cancer cells directly correlates with eradication by antitransferrin recombinant immunotoxin.
We determined the efficacy of HB21(Fv)PE40, a single-chain immunotoxin made by fusing the variable regions of a monoclonal… 
Highly Cited
1999
Highly Cited
1999
The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake.
Recent studies have demonstrated that the protein product (natural resistance associated macrophage protein 2, Nramp2) encoded by… 
Highly Cited
1997
Highly Cited
1997
Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line.
Iron regulatory proteins (IRPs) are cytoplasmic RNA binding proteins that are central components of a sensory and regulatory… 
1997
1997
Percentile estimates for transferrin receptor in normal infants 9-15 mo of age.
To establish percentile estimates of transferrin receptor (TfR) for healthy infants, plasma TfR was measured in 485 healthy… 
Review
1992
Review
1992
Coordination of cellular iron metabolism by post-transcriptional gene regulation.
Highly Cited
1992
Highly Cited
1992
Monoclonal antibodies against defined epitopes of the human transferrin receptor cytoplasmic tail.
Highly Cited
1990
Highly Cited
1990
Structural requirements of iron-responsive elements for binding of the protein involved in both transferrin receptor and ferritin mRNA post-transcriptional regulation.
The synthesis of both transferrin receptor (TfR) and ferritin is regulated post-transcriptionally by iron. This is mediated by… 
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