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TCF4 protein, human

Known as: transcription factor 4 protein, human, Class B Basic Helix-Loop-Helix Protein 19, Immunoglobulin transcription factor 2, human 
Transcription factor 4 (667 aa, ~71 kDa) is encoded by the human TCF4 gene. This protein plays a role in the regulation of immunoglobulin… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsTRANSCRIPTION FACTOR
DNA-Binding ProteinsGenes, RegulatorTCF4 geneTCF7L2 gene

Papers overview

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Highly Cited
2017
Highly Cited
2017
Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2…
An excess of glucocorticoids (GCs) is reported to be one of the most common causes of osteonecrosis of the femoral head (ONFH… 
Highly Cited
2012
Highly Cited
2012
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.
Mutations leading to expansion of a poly-glutamine track in Huntingtin (Htt) cause Huntington's disease (HD). Signs of… 
Highly Cited
2012
Highly Cited
2012
Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes
Aims/hypothesisThere is convincing evidence that endoplasmic reticulum (ER) stress is implicated in the pathogenesis of diabetes… 
Highly Cited
2011
Highly Cited
2011
Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE-19/HPV-16 cells.
PURPOSE Oxidative stress plays an important role in the pathogenesis of various ocular diseases such as retinopathy, glaucoma… 
Review
2008
Review
2008
Activating transcription factor 4.
Highly Cited
2008
Highly Cited
2008
ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo
Oxidative stress is pathogenic in neurological diseases, including stroke. The identity of oxidative stress–inducible… 
Highly Cited
2008
Highly Cited
2008
Improved production of recombinant human antithrombin III in Chinese hamster ovary cells by ATF4 overexpression
To improve the production of recombinant human antithrombin III (AT‐III) in Chinese hamster ovary (CHO) cells, the genes encoding… 
Highly Cited
2008
Highly Cited
2008
CCAAT/enhancer-binding protein beta promotes osteoblast differentiation by enhancing Runx2 activity with ATF4.
Although CCAAT/enhancer-binding protein beta (C/EBPbeta) is involved in osteocalcin gene expression in osteoblast in vitro, the… 
Highly Cited
2004
Highly Cited
2004
Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress
ABSTRACT Hypoxic stress results in a rapid and sustained inhibition of protein synthesis that is at least partially mediated by… 
Highly Cited
1997
Highly Cited
1997
Characterization of Human Activating Transcription Factor 4, a Transcriptional Activator That Interacts with Multiple Domains of cAMP-responsive Element-binding Protein (CREB)-binding Protein (CBP)*
We demonstrate that human activating transcription factor 4 (hATF4), a member of the activating transcription factor/cAMP… 
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