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TBX21 wt Allele

Known as: T-bet, TBET, TBLYM 
Human TBX21 wild-type allele is located in the vicinity of 17q21.32 and is approximately 13 kb in length. This allele, which encodes T-box… 
National Institutes of Health

Related topics

Related topics

6 relations
17q21.32Homo sapiensMigration, CellTranscription, Genetic

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Ezh2 Regulates Transcriptional and Posttranslational Expression of T-bet and Promotes Th1 Cell Responses Mediating Aplastic Anemia in Mice
Acquired aplastic anemia (AA) is a potentially fatal bone marrow (BM) failure syndrome. IFN-γ–producing Th1 CD4+ T cells mediate… 
2012
2012
Decreased STAT5 phosphorylation and GATA‐3 expression in NOX2‐deficient T cells: Role in T helper development
Absence of phagocyte NADPH oxidase (NOX2) activity causes chronic granulomatous disease (CGD), a primary immunodeficiency… 
2010
2010
Maternal endotoxin exposure attenuates allergic airway disease in infant rats.
Prenatal exposures to immunogenic stimuli, such as bacterial LPS, have shown to influence the neonatal immune system and lung… 
2009
2009
Expression of Regulatory T–Cell-Related Molecule Genes and Clinical Outcome in Kidney Transplant Recipients
Background. Naturally occurring regulatory T cells have been associated with long-term allograft survival. We investigated… 
Review
2009
Review
2009
An essential interaction between T-box proteins and histone-modifying enzymes
Cellular differentiation requires precisely coordinated events to induce developmentally appropriate gene expression profiles… 
Highly Cited
2005
Highly Cited
2005
5-Aminoimidazole-4-Carboxamide Ribonucleoside: A Novel Immunomodulator with Therapeutic Efficacy in Experimental Autoimmune Encephalomyelitis1
Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, is a Th1-mediated inflammatory… 
Highly Cited
2005
Highly Cited
2005
mRNA Quantification of T-bet, GATA-3, IFN-γ, and IL-4 Shows a Defective Th1 Immune Response in the Peripheral Blood from Rheumatoid Arthritis Patients: Link with Disease Activity
A T helper (Th)1 cytokine profile is predominant in the inflamed synovium of rheumatoid arthritis (RA). Since the situation in… 
2005
2005
Interleukin-12 and -18 levels in peritoneal dialysate effluent correlate with the outcome of peritonitis in patients undergoing peritoneal dialysis: implications for the Type I/Type II T-cell immune…
BACKGROUND We previously showed that a positive impact of peritoneal defense response on the outcome of peritoneal dialysis (PD… 
Highly Cited
2003
Highly Cited
2003
Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation
Activation of naive T cells through the TCR and cytokine signals directs their differentiation into effector or memory subsets… 
2003
2003
Different antigens trigger different Th1/Th2 reactions in neonatal mononuclear cells (MNCs) relating to T‐bet/GATA‐3 expression
Neonates are known to have poor cellular immunity, especially poor Th1 response. We investigated how neonatal mononuclear cells… 
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