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Identification of a major co-receptor for primary isolates of HIV-1
The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, Mip-1α and MIP-1β. Expand
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.
A novel diphtheria toxin-based system that allows the inducible, short-term ablation of dendritic cells (DC) in vivo is reported and it is shown that in vivo DC are required to cross-prime CTL precursors. Expand
Requirement for RORgamma in thymocyte survival and lymphoid organ development.
It is shown that mice lacking the orphan nuclear hormone receptor RORgamma lose thymic expression of the anti-apoptotic factor Bcl-xL, which regulates the survival of CD4+8+ thymocytes and may control the temporal window during which thymocyte can undergo positive selection. Expand
Expression cloning of new receptors used by simian and human immunodeficiency viruses
Two members of the seven-transmembrane G-protein-coupled receptor family that are used not only by SIVs, but also by strains of HIV-2 and M-tropic HIV-1 are identified. Expand
Flexible use of nuclear import pathways by HIV-1.
A fragment of the cleavage and polyadenylation factor 6, CPSF6, is identified as a potent inhibitor of HIV-1 infection and highlights a single residue in CA as essential in regulating interactions with NUPs. Expand
GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3+ regulatory T cells
It is demonstrated that platelets and activated Tregs co-express latent TGF-β and GARP on their membranes and that GARP or LRRC32, a leucine-rich repeat molecule of unknown function, is critical for tethering T GF-β to the cell surface. Expand
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
These studies identify RORγt as having a central function in the differentiation of human TH-17 cells from naive CD4+ T cells and suggest that similar cytokine pathways are involved in this process in mice and humans. Expand
Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.
It is shown that zymosan, a stimulus for TLR2 and dectin-1, regulates cytokine secretion in DCs and macrophages to induce immunological tolerance and suggest several targets for pharmacological modulation of immune responses in various clinical settings. Expand
Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire1
  • James J. Campbell, Shixin Qin, +5 authors E. Butcher
  • Biology, Medicine
  • The Journal of Immunology
  • 1 June 2001
A diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types are described. Expand
Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions
It is proposed that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse. Expand