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TAK-242

Known as: TAK 242, TAK242 
National Institutes of Health

Papers overview

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2020
2020
Microglial responses after phagocytosis: Escherichia coli bioparticles, but not cell debris or amyloid beta, induce matrix metalloproteinase‐9 secretion in cultured rat primary microglial cells
Upon infection or brain damage, microglia are activated to play roles in immune responses, including phagocytosis and soluble… 
2020
2020
TAK-242, Toll-Like Receptor 4 Antagonist, Attenuates Brain Edema in Subarachnoid Hemorrhage Mice.
BACKGROUND Brain edema is a common and critical pathology following subarachnoid hemorrhage (SAH). Toll-like receptor 4 (TLR4… 
2019
2019
Study on the immunomodulatory activity of a novel polysaccharide from the lichen Umbilicaria Esculenta.
2019
2019
Effects of β2/aβ2 on oxLDL-induced CD36 activation in THP-1 macrophages.
2017
2017
TAK-242 Protects Against Apoptosis in Coronary Microembolization-Induced Myocardial Injury in Rats by Suppressing TLR4/NF-κB Signaling Pathway
Background/Aims: Myocardial apoptosis is heavily implicated in the myocardial injury caused by coronary microembolization (CME… 
2017
2017
Immunoregulatory Role of MicroRNA-21 in Macrophages in Response to Bacillus Calmette-Guerin Infection Involves Modulation of the TLR4/MyD88 Signaling Pathway
Background/Aims: The purpose of this study is to explore the immunoregulatory role of microRNA-21 (miR-21) targeting of the TLR4… 
2017
2017
A novel function of TLR4 in mediating the immunomodulatory effect of Benzanthrone, an environmental pollutant.
Review
2014
Review
2014
What's new in the quagmire of sepsis?
2013
2013
Both NF-κB and c-Jun/AP-1 involved in anti-β2GPI/β2GPI-induced tissue factor expression in monocytes
Summary Our previous data has demonstrated that Toll-like receptor 4 (TLR4) and its signalling pathway can contribute to anti-β2… 
2011
2011
TAKEDA-143242 increased survival via reduced cytokines in porcine peritonitis.
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