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Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*
Objective:To determine the prevalence and impact on mortality of delays in initiation of effective antimicrobial therapy from initial onset of recurrent/persistent hypotension of septic shock.Expand
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Profound but reversible myocardial depression in patients with septic shock.
To characterize the role of cardiac function in septic shock, serial radionuclide cineangiographic and hemodynamic evaluations were done on 20 patients with documented septic shock. Although allExpand
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Pathogenetic mechanisms of septic shock.
  • J. Parrillo
  • Medicine
  • The New England journal of medicine
  • 20 May 1993
One of the most frequent and serious problems confronting clinicians is the management of a serious infection and the systemic response to infection, a syndrome termed sepsis. When this syndromeExpand
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Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival.
STUDY OBJECTIVE To study early microcirculatory perfusion indices in patients with severe sepsis/septic shock, compare early microcirculatory indices in sepsis survivors versus nonsurvivors, andExpand
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The cardiovascular response of normal humans to the administration of endotoxin.
Marked abnormalities in cardiovascular function accompany septic shock, and bacterial endotoxin is believed to be one of the principal mediators of these abnormalities. To evaluate the cardiovascularExpand
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Clinical review: Myocardial depression in sepsis and septic shock
Myocardial dysfunction frequently accompanies severe sepsis and septic shock. Whereas myocardial depression was previously considered a preterminal event, it is now clear that cardiac dysfunction asExpand
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Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy.
Septic shock is the commonest cause of death in intensive care units. Although sepsis usually produces a low systemic vascular resistance and elevated cardiac output, strong evidence (decreasedExpand
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Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality.
CONTEXT Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking. OBJECTIVE To testExpand
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We sought to determine (a) if early lactate clearance is associated with improved survival in emergency department patients with severe sepsis and (b) the concordance between central venous oxygenExpand
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Vasopressor and inotropic support in septic shock: An evidence-based review
Objective:In 2003, critical care and infectious disease experts representing 11 international organizations developed management guidelines for vasopressor and inotropic support in septic shock thatExpand
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