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Objective and background: Pulmonary fibrosis in sarcoidosis is a significant cause of morbidity and mortality. Various factors… Expand Stroke causes brain injury in millions of people world wide each year. Despite the enormity of problem, currently there is no… Expand OBJECT
Delayed cerebral ischemia remains an important cause of death and disability in patients who have suffered subarachnoid… Expand Object. Delayed cerebral ischemia remains an important cause of death and disability in patients who have suffered subarachnoid… Expand Hepatic levels of a powerful vasoconstrictor endothelin-1 (ET-1) and its receptors increase in human and carbon tetrachloride… Expand BACKGROUND
Although local inhibition of the generation or actions of endothelin-1 has been shown to cause forearm vasodilatation… Expand 1 We examined the effects of systemic infusion, in healthy human volunteers, of the endothelin antagonist TAK‐044 on the plasma… Expand 1 The aims of the present study were to characterize the pharmacological profile of a new endothelin (ET) receptor antagonist… Expand Protective effects of a new endothelin (ET) receptor antagonist, TAK-044, were studied in a model of acute renal failure (ARF) in… Expand The present study describes the pharmacological profile of an endothelin (ET) receptor antagonist, TAK-044, in anesthetized rats… Expand