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Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects.
- Y. Ben-Shlomo, M. Spears, +28 authors I. Wilkinson
- Journal of the American College of Cardiology
- 25 February 2014
Consideration of aPWV improves model fit and reclassifies risk for future CVD events in models that include standard risk factors and may enable better identification of high-risk populations that might benefit from more aggressive CVD risk factor management. Expand
The influence of heart rate on augmentation index and central arterial pressure in humans
- I. Wilkinson, H. MacCallum, L. Flint, J. Cockcroft, D. Newby, D. Webb
- The Journal of physiology
- 1 May 2000
An inverse, linear relationship between AIx is demonstrated, likely due to alterations in the timing of the reflected pressure wave, produced by changes in the absolute duration of systole, which may explain the lack of rise in central systolic pressure during incremental pacing despite an increase in peripheral pressure. Expand
Noninvasive assessment of arterial stiffness and risk of atherosclerotic events.
The effects of current and future cardiovascular drugs on arterial stiffness are discussed, as is the relationship between arterial elasticity and endothelial function. Expand
Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis
PWA is a simple and reproducible technique with which to measure PWV and AIx and may, therefore, be suitable for large-scale population and intervention studies investigating the clinical relevance of vascular stiffness. Expand
Pulse transit time measured from the ECG: an unreliable marker of beat-to-beat blood pressure.
The relationship between rPTT, preejection period (PEP; the R-wave/mechanical cardiac delay), and BP would vary with different vasoactive drugs, but the relationship is not reliable enough to be used as a surrogate marker of SBP, although it may be useful in assessing BP variability. Expand
Endothelin as a regulator of cardiovascular function in health and disease
Results of most studies suggest that generation of, or sensitivity to, endothelin-1 is no greater in hypertensive than it is in normotensive subjects, but the deleterious vascular effects of endogenous endotheli-1 may be accentuated by reduced generation of nitric oxide caused by hypertensive endothelial dysfunction. Expand
Circulating microRNAs as potential markers of human drug‐induced liver injury
This work provides the first evidence for the potential use of miRNAs as biomarkers of human drug‐induced liver injury by examining these molecules, for the first time, in humans with APAP poisoning. Expand
Oxidized Phospholipid Inhibition of Toll-like Receptor (TLR) Signaling Is Restricted to TLR2 and TLR4
- C. Erridge, S. Kennedy, C. Spickett, D. Webb
- Biology, Medicine
- Journal of Biological Chemistry
- 5 September 2008
Results suggest that oxidized phospholipid-mediated inhibition of TLR signaling occurs mainly by competitive interaction with accessory proteins that interact directly with bacterial lipids to promote signaling via TLR2 or TLR4. Expand
Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the…
The most relevant methodological issues in the research on endothelial function and dysfunction are summarized in this paper. Expand
Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European…
This paper will provide a concise overview of the mechanisms causing endothelial dysfunction in the different cardiovascular risk factors and disease conditions, and of the impact of the intervention measures and treatments. Expand