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Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects.
- Y. Ben-Shlomo, M. Spears, +28 authors I. Wilkinson
- Journal of the American College of Cardiology
- 25 February 2014
OBJECTIVES The goal of this study was to determine whether aortic pulse wave velocity (aPWV) improves prediction of cardiovascular disease (CVD) events beyond conventional risk factors. BACKGROUND… Expand
The influence of heart rate on augmentation index and central arterial pressure in humans
- I. Wilkinson, H. MacCallum, L. Flint, J. Cockcroft, D. Newby, D. Webb
- The Journal of physiology
- 1 May 2000
1 Arterial stiffness is an important determinant of cardiovascular risk. Augmentation index (AIx) is a measure of systemic arterial stiffness derived from the ascending aortic pressure waveform. The… Expand
The Deacon Cell and the other meridional cells of the Southern ocean
Abstract The meridional circulation cells of the Southern Ocean are investigated using the results from a fine-resolution primitive equation model. Zonal integration along depth levels shows the… Expand
Noninvasive assessment of arterial stiffness and risk of atherosclerotic events.
Investigation of arterial stiffness, especially of the large arteries, has gathered pace in recent years with the development of readily available noninvasive assessment techniques. These include the… Expand
Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis
Objective The aim of this study was to determine the reproducibility of pulse wave velocity (PWV) and augmentation index (AIx) measured using pulse wave analysis (PWA), prior to its use in… Expand
Pulse transit time measured from the ECG: an unreliable marker of beat-to-beat blood pressure.
The arterial pulse-wave transit time can be measured between the ECG R-wave and the finger pulse (rPTT), and has been shown previously to have a linear correlation with blood pressure (BP). We… Expand
Endothelin as a regulator of cardiovascular function in health and disease
The endothelins are a family of endothelium-derived peptides that possess characteristically sustained vasoconstrictor properties. Endothelin-1 appears to be the predominant member of the family… Expand
Oxidized Phospholipid Inhibition of Toll-like Receptor (TLR) Signaling Is Restricted to TLR2 and TLR4
- C. Erridge, S. Kennedy, C. Spickett, D. Webb
- Biology, Medicine
- Journal of Biological Chemistry
- 5 September 2008
The generation of reactive oxygen species is a central feature of inflammation that results in the oxidation of host phospholipids. Oxidized phospholipids, such as… Expand
Circulating microRNAs as potential markers of human drug‐induced liver injury
New biomarkers of liver injury are required in the clinic and in preclinical pharmaceutical evaluation. Previous studies demonstrate that two liver‐enriched microRNAs (miR‐122 and miR‐192) are… Expand
Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the…
An enormous number of studies in the last two decades have been devoted to investigating the role of the endothelium in cardiovascular diseases. Nonetheless, the optimal methodology for investigating… Expand