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T0156

Known as: T-0156 
 
National Institutes of Health

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2 relations

Broader (2)

NaphthyridinesPyrimidines

Papers overview

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2014
2014
Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5
The involvement of nitric oxide (NO) and cyclic GMP (cGMP) in neurogenesis has been progressively unmasked over the last decade… Expand
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2011
2011
Stimulus-specific blockade of nitric oxide-mediated dilatation by asymmetric dimethylarginine (ADMA) and monomethylarginine (L-NMMA) in rat aorta and carotid artery.
Previous work on female rat aorta has shown that although monomethylarginine (L-NMMA) and asymmetric dimethylarginine (ADMA) each… Expand
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2011
2011
Phosphodiesterase inhibitors block the acceleration of skin permeability barrier repair by red light
Abstract:  We previously demonstrated that exposure to red light (550–670 nm) accelerates epidermal permeability barrier recovery… Expand
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2008
2008
Desensitization of the soluble guanylyl cyclase/cGMP pathway by lipopolysaccharide in rat isolated pulmonary artery but not aorta
To investigate the function of soluble guanylyl cyclase (sGC)/3′,5′‐cyclic guanosine monophosphate (cGMP) pathway in… Expand
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2008
2008
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.
Cyclic nucleotides (cAMP and cGMP) are the main second messengers linked to vasodilatation. They are synthesized by cyclases and… Expand
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2008
2008
Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor.
The efficacy of nitroglycerin as a vasodilator is limited by tolerance, which develops shortly after treatment begins. The… Expand
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2004
2004
T-0156, a novel phosphodiesterase type 5 inhibitor, and sildenafil have different pharmacological effects on penile tumescence and electroretinogram in dogs.
T-0156 (2-(2-methylpyridin-4-yl)methyl-4-(3,4,5-trimethoxyphenyl)-8-(pyrimidin-2-yl)methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3… Expand
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Highly Cited
2003
Highly Cited
2003
[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP.
Sildenafil (Viagra) potentiates penile erection by acting as a nonhydrolyzable analog of cGMP and competing with this nucleotide… Expand
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2003
2003
1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors.
Novel 1,7- and 2,7-naphthyridine derivatives, designed by the introduction of nitrogen atom into the phenyl ring of previously… Expand
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2002
2002
Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor.
The enzymological and pharmacological properties of 2-(2-Methylpyridin-4-yl)methyl-4-(3,4,5-trimethoxyphenyl)-8-(pyrimidin-2-yl… Expand
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