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T0156

Known as: T-0156 
National Institutes of Health

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2 relations

Broader (2)

NaphthyridinesPyrimidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5
The involvement of nitric oxide (NO) and cyclic GMP (cGMP) in neurogenesis has been progressively unmasked over the last decade… 
2012
2012
Role of new agents affecting NO/cGMP pathway on ovalbumin-sensitized guinea pig trachea
ABSTRACT Asthma is a chronic inflammatory disease in which cell components play important roles. We aimed to evaluate the effects… 
2011
2011
Stimulus-specific blockade of nitric oxide-mediated dilatation by asymmetric dimethylarginine (ADMA) and monomethylarginine (L-NMMA) in rat aorta and carotid artery.
2011
2011
Phosphodiesterase inhibitors block the acceleration of skin permeability barrier repair by red light
Abstract:  We previously demonstrated that exposure to red light (550–670 nm) accelerates epidermal permeability barrier recovery… 
2010
2010
Prostanoid TP receptor-mediated impairment of cyclic AMP-dependent vasorelaxation is reversed by phosphodiesterase inhibitors.
2008
2008
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.
2008
2008
Desensitization of the soluble guanylyl cyclase/cGMP pathway by lipopolysaccharide in rat isolated pulmonary artery but not aorta
To investigate the function of soluble guanylyl cyclase (sGC)/3′,5′‐cyclic guanosine monophosphate (cGMP) pathway in… 
2004
2004
T-0156, a novel phosphodiesterase type 5 inhibitor, and sildenafil have different pharmacological effects on penile tumescence and electroretinogram in dogs.
Highly Cited
2003
Highly Cited
2003
[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP.
Sildenafil (Viagra) potentiates penile erection by acting as a nonhydrolyzable analog of cGMP and competing with this nucleotide… 
2002
2002
Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor.
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