Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

T-cell protein tyrosine phosphatase

Known as: T Cell Protein Tyrosine Phosphatase, Protein Tyrosine Phosphatase, Non Receptor Type 2, Protein Tyrosine Phosphatase, Non-Receptor Type 2 [Chemical/Ingredient] 
A subtype of non-receptor protein tyrosine phosphatase that is closely-related to PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1. Alternative… Expand
National Institutes of Health

Related topics

Related topics

12 relations
In BloodPTPN2 geneProcess of secretionantagonists & inhibitors
Expand

Narrower (4)

Protein Tyrosine Phosphatase, Non-Receptor Type 2, TC45 IsoformProtein Tyrosine Phosphatase, Non-Receptor Type 2, TC48 IsoformPtpn2 protein, mousePtpn2 protein, rat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.
Many autoimmune diseases exhibit familial aggregation, indicating that they have genetic determinants. Single nucleotide… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Selective regulation of tumor necrosis factor–induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase
The proinflammatory cytokine tumor necrosis factor (TNF) modulates cellular responses through the mitogen-activated protein… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease.
The deregulation of the immune response is a critical component in inflammatory disease. Recent in vitro data show that T-cell… Expand
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Site-Selective Regulation of Platelet-Derived Growth Factor β Receptor Tyrosine Phosphorylation by T-Cell Protein Tyrosine Phosphatase
ABSTRACT The platelet-derived growth factor (PDGF) β receptor mediates mitogenic and chemotactic signals. Like other tyrosine… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase
ABSTRACT Upon interferon (IFN) stimulation, Stat1 becomes tyrosine phosphorylated and translocates into the nucleus, where it… Expand
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The T Cell Protein Tyrosine Phosphatase Is a Negative Regulator of Janus Family Kinases 1 and 3
BACKGROUND The immune response is regulated through a tightly controlled cytokine network. The counteracting balance between… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Structure Determination of T Cell Protein-tyrosine Phosphatase*
Protein-tyrosine phosphatase 1B (PTP1B) has recently received much attention as a potential drug target in type 2 diabetes. This… Expand
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation.
In the previous study, we demonstrated that the nuclear isoform of T-cell protein-tyrosine phosphatase (TC-PTP) dephosphorylated… Expand
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Epidermal Growth Factor Receptor and the Adaptor Protein p52Shc Are Specific Substrates of T-Cell Protein Tyrosine Phosphatase
ABSTRACT T-cell protein tyrosine phosphatase (TCPTP) exists as two forms generated by alternative splicing: a 48-kDa endoplasmic… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase–deficient Mice
The T cell protein tyrosine phosphatase (TC-PTP) is one of the most abundant mammalian tyrosine phosphatases in hematopoietic… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • table 2
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE