T-cell protein tyrosine phosphatase

Known as: T Cell Protein Tyrosine Phosphatase, Protein Tyrosine Phosphatase, Non Receptor Type 2, Protein Tyrosine Phosphatase, Non-Receptor Type 2 [Chemical/Ingredient] 
A subtype of non-receptor protein tyrosine phosphatase that is closely-related to PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1. Alternative… (More)
National Institutes of Health

Related topics

Related topics

11 relations
In BloodPTPN2 geneProcess of secretionantagonists & inhibitors
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Narrower (3)

Protein Tyrosine Phosphatase, Non-Receptor Type 2, TC45 IsoformProtein Tyrosine Phosphatase, Non-Receptor Type 2, TC48 IsoformPtpn2 protein, mouse

Papers overview

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Highly Cited
2011
Highly Cited
2011
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.
Many autoimmune diseases exhibit familial aggregation, indicating that they have genetic determinants. Single nucleotide… (More)
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2010
2010
T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis
OBJECTIVE Insulin-induced phosphatidylinositol 3-kinase (PI3K)/Akt signaling and interleukin-6 (IL-6)-instigated JAK/STAT3… (More)
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Highly Cited
2004
Highly Cited
2004
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease.
The deregulation of the immune response is a critical component in inflammatory disease. Recent in vitro data show that T-cell… (More)
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Highly Cited
2002
Highly Cited
2002
The T Cell Protein Tyrosine Phosphatase Is a Negative Regulator of Janus Family Kinases 1 and 3
BACKGROUND The immune response is regulated through a tightly controlled cytokine network. The counteracting balance between… (More)
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2002
2002
Structure determination of T cell protein-tyrosine phosphatase.
Protein-tyrosine phosphatase 1B (PTP1B) has recently received much attention as a potential drug target in type 2 diabetes. This… (More)
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Highly Cited
2002
Highly Cited
2002
Identification of a Nuclear Stat 1 Protein Tyrosine Phosphatase
Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase Johanna ten Hoeve, Maria de Jesus Ibarra-Sanchez, Yubin Fu, Wei… (More)
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Highly Cited
1998
Highly Cited
1998
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.
T-cell protein tyrosine phosphatase (TCPTP) exists as two forms generated by alternative splicing: a 48-kDa endoplasmic reticulum… (More)
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Highly Cited
1997
Highly Cited
1997
Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase–deficient Mice
The T cell protein tyrosine phosphatase (TC-PTP) is one of the most abundant mammalian tyrosine phosphatases in hematopoietic… (More)
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1997
1997
Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97.
Alternative splicing of the T-cell protein tyrosine phosphatase (TCPTP) transcript generates two forms of the enzyme that differ… (More)
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Highly Cited
1995
Highly Cited
1995
COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus
The noncatalytic domain of the human T cell protein tyrosine phosphatase (TCPTP) is alternatively spliced to generate a 45-kD… (More)
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