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- Publications
- Influence
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI
- T. Khan, E. Muise, +7 authors P. Scherer
- Biology, Medicine
- Molecular and Cellular Biology
- 29 December 2008
ABSTRACT Adipocytes are embedded in a unique extracellular matrix whose main function is to provide mechanical support, in addition to participating in a variety of signaling events. During adipose… Expand
Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor γ and Altered Metabolic States
- E. Muise, B. Azzolina, +7 authors K. Wong
- Biology, Medicine
- Molecular Pharmacology
- 1 August 2008
Adipose tissue is a metabolically responsive endocrine organ that secretes a myriad of adipokines. Antidiabetic drugs such as peroxisome proliferator-activated receptor (PPAR) γ agonists target… Expand
SirT1 Regulates Adipose Tissue Inflammation
- Matthew P Gillum, M. Kotas, +14 authors G. Shulman
- Biology, Medicine
- Diabetes
- 13 November 2011
OBJECTIVE Macrophage recruitment to adipose tissue is a reproducible feature of obesity. However, the events that result in chemokine production and macrophage recruitment to adipose tissue during… Expand
Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase–deficient Mice
- K. E. You-Ten, E. Muise, +5 authors M. Tremblay
- Biology, Medicine
- The Journal of experimental medicine
- 29 August 1997
The T cell protein tyrosine phosphatase (TC-PTP) is one of the most abundant mammalian tyrosine phosphatases in hematopoietic cells; however, its role in hematopoietic cell function remains unknown.… Expand
Anti-Diabetic Efficacy and Impact on Amino Acid Metabolism of GRA1, a Novel Small-Molecule Glucagon Receptor Antagonist
- J. Mu, S. Qureshi, +12 authors B. Zhang
- Chemistry, Medicine
- PloS one
- 19 November 2012
Hyperglucagonemia is implicated in the pathophysiology of hyperglycemia. Antagonism of the glucagon receptor (GCGR) thus represents a potential approach to diabetes treatment. Herein we report the… Expand
Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In vivo
- Shira Landskroner-Eiger, Bin-Zhi Qian, +7 authors P. Scherer
- Biology, Medicine
- Clinical Cancer Research
- 15 May 2009
Purpose: Adipocytes represent one of the most abundant constituents of the mammary gland. They are essential for mammary tumor growth and survival. Metabolically, one of the more important… Expand
Downstream Signaling Pathways in Mouse Adipose Tissues Following Acute In Vivo Administration of Fibroblast Growth Factor 21
- E. Muise, Sandra Souza, +18 authors H. Mehmet
- Biology, Medicine
- PloS one
- 6 September 2013
FGF21 is a novel secreted protein with robust anti-diabetic, anti-obesity, and anti-atherogenic activities in preclinical species. In the current study, we investigated the signal transduction… Expand
Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma…
- John J. Acton, T. Akiyama, +16 authors H. Wood
- Chemistry, Medicine
- Journal of medicinal chemistry
- 9 June 2009
Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists are used to treat type 2 diabetes mellitus (T2DM). Widespread use of PPARgamma agonists has been prevented due to adverse effects… Expand
Comparison of inhibition of ovalbumin-induced bronchoconstriction in guinea pigs and in vitro inhibition of tumor necrosis factor-alpha formation with phosphodiesterase 4 (PDE4) selective inhibitors.
- E. Muise, I. Chute, +7 authors J. Mancini
- Biology, Medicine
- Biochemical pharmacology
- 15 April 2002
Phosphodiesterase 4 (PDE4) inhibitors elevate cyclic adenosine 5'-monophosphate (cAMP), and this elevation has been shown to inhibit inflammatory cytokines such as tumor necrosis factor-alpha… Expand
A novel selective peroxisome proliferator-activator receptor-gamma modulator-SPPARgammaM5 improves insulin sensitivity with diminished adverse cardiovascular effects.
- C. H. Chang, Lesley Mcnamara, +8 authors M. McCann
- Medicine
- European journal of pharmacology
- 14 April 2008
The use of the thiazolidinedione insulin sensitizers rosiglitazone and pioglitazone for the treatment of type 2 diabetes mellitus in recent years has proven to be effective in helping patients resume… Expand